Matti S. Aapro
马蒂·阿波罗
MD, FRCR (Hon)
Founder and Emeritus Medical Director创始人及荣休医疗主任
👥Biography 个人简介
Matti S. Aapro, MD, FRCR (Hon) is Founder and Emeritus Medical Director of the Genolier Cancer Centre in Switzerland and one of the world's most recognized authorities on supportive care in oncology, particularly chemotherapy-induced nausea and vomiting (CINV). As a longtime president and scientific leader of the Multinational Association of Supportive Care in Cancer (MASCC), Dr. Aapro has been the principal architect of the MASCC/ESMO antiemetic guidelines, which are adopted by oncology programs worldwide. He contributed to the clinical development of multiple antiemetic agents including NK1 receptor antagonists (aprepitant, netupitant) and second-generation 5-HT3 antagonists (palonosetron), and has led numerous randomized trials and systematic reviews establishing optimal prophylactic antiemetic regimens for highly and moderately emetogenic chemotherapy. Dr. Aapro has also made seminal contributions to the management of myelosuppression, anemia of cancer, and febrile neutropenia. He has published over 500 peer-reviewed papers and book chapters and has received honorary degrees and fellowships from institutions across Europe and North America.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
MASCC/ESMO Antiemetic Guidelines Development
Served as principal developer and long-standing chair of the MASCC antiemetic guidelines panel, producing evidence-based, globally adopted recommendations for CINV prevention using 5-HT3 antagonists, NK1 antagonists, and dexamethasone across emetogenic risk categories.
NK1 Antagonist and Palonosetron Clinical Development
Led and participated in pivotal randomized trials evaluating aprepitant, fosaprepitant, netupitant-palonosetron (NEPA), and palonosetron for CINV prevention, establishing the triple-antiemetic regimen standard for highly emetogenic chemotherapy.
Supportive Care in Oncology: Neutropenia and Anemia
Contributed foundational clinical evidence for G-CSF use in febrile neutropenia prophylaxis and erythropoiesis-stimulating agents in cancer-related anemia, informing multiple international practice guidelines.
Representative Works 代表性著作
2016 MASCC and ESMO Guideline Update for the Prevention of Chemotherapy- and Radiotherapy-Induced Nausea and Vomiting
Annals of Oncology (2016)
Comprehensive MASCC/ESMO guideline update establishing evidence-based antiemetic prophylaxis recommendations adopted by oncology centers worldwide.
Netupitant and Palonosetron for the Prevention of Chemotherapy-Induced Nausea and Vomiting
Annals of Oncology (2014)
Phase III randomized trial establishing fixed-dose NEPA combination as superior to palonosetron alone for prevention of CINV after highly emetogenic chemotherapy.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-20 | All information from publicly available academic sources
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