Matthew F. Krummel
马修·克鲁梅尔
PhD
Professor and Vice Chair of Research, Department of Pathology病理系研究副主任兼教授
👥Biography 个人简介
Matthew Krummel at UCSF is the co-discoverer of CTLA-4 as an inhibitory checkpoint and a pioneer of intravital two-photon microscopy for studying immune cell dynamics in tumors. His work bridging PD-1/CTLA-4 checkpoint biology with real-time imaging has fundamentally advanced understanding of T cell exhaustion and tumor immune exclusion.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Co-Discovery of CTLA-4 as Immune Checkpoint
Co-authored with James Allison the original 1995 Journal of Experimental Medicine study showing that CTLA-4 blockade with antibodies enhances T cell activation—the founding experiment behind ipilimumab and the checkpoint blockade revolution.
Intravital Two-Photon Imaging of Tumor Immunity
Developed and applied intravital two-photon microscopy to visualize T cell motility, contact dynamics, and functional states within live tumors, revealing how physical and metabolic barriers enforce immune exclusion and T cell dysfunction.
PD-1 and T Cell Dysfunction Mechanisms
Elucidated molecular mechanisms by which PD-1 signaling disrupts TCR signal transduction and cytoskeletal reorganization at the immune synapse, explaining how tumors exploit PD-L1 to disable infiltrating T cells locally.
Representative Works 代表性著作
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
Journal of Experimental Medicine (1995)
Seminal paper demonstrating CTLA-4 as a negative regulator of T cell activation, providing the conceptual and experimental foundation for checkpoint immunotherapy.
Visualizing tumour immunity
Nature Reviews Immunology (2014)
Comprehensive review of intravital imaging approaches for studying immune cell behavior in tumors, establishing best practices and key findings from live tumor imaging studies.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
关注 马修·克鲁梅尔 的研究动态
Follow Matthew F. Krummel's research updates
留下邮箱，当我们发布与 Matthew F. Krummel（University of California, San Francisco）相关的新研究或访谈时，我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment