Martine Piccart
玛尔蒂娜·皮卡特
MD, PhD
Professor of Oncology; Past President, EORTC; Founder, Breast International Group (BIG)肿瘤学教授；欧洲癌症研究与治疗组织前主席；国际乳腺癌研究组创始人
👥Biography 个人简介
Europe's most influential breast cancer drug developer and clinical trialist. Led pivotal trials establishing trastuzumab, pertuzumab, T-DM1, and CDK4/6 inhibitors as standards of care. Founder of the Breast International Group (BIG) and former EORTC president.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
HER2-Targeted Drug Development
Led or co-led landmark trials for trastuzumab, pertuzumab, and T-DM1 in HER2-positive breast cancer, establishing current standards and saving millions of lives.
CDK4/6 Inhibitor Trials
Played central role in MONALEESA and MONARCH trials demonstrating PFS and OS benefit of CDK4/6 inhibitors in hormone receptor-positive advanced breast cancer.
International Trial Infrastructure
Founded the Breast International Group (BIG), creating a global network enabling definitive large-scale breast cancer trials across continents.
Representative Works 代表性著作
Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer (CLEOPATRA)
New England Journal of Medicine (2012)
CLEOPATRA trial showing pertuzumab+trastuzumab combination significantly prolonged survival in HER2-positive metastatic breast cancer.
Adjuvant lapatinib and trastuzumab for early HER2-positive breast cancer (ALTTO)
New England Journal of Medicine (2014)
Large international trial that shaped understanding of dual HER2 blockade and optimal adjuvant sequencing in early disease.
Ribociclib plus letrozole for advanced breast cancer (MONALEESA-2)
New England Journal of Medicine (2016)
Established ribociclib plus letrozole as a highly effective first-line option in HR+/HER2- advanced breast cancer.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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