Scott Lowe
斯科特·洛
PhD
Chair, Cancer Biology and Genetics Program; Geoffrey Beene Cancer Research Center Member癌症生物学与遗传学项目主任；杰弗里·宾肿瘤研究中心成员
👥Biography 个人简介
World authority on tumor suppressor networks, apoptosis, and senescence in cancer drug response. His work on p53, RAS, and therapy-induced senescence has directly informed the development of new cancer therapeutics and resistance mechanisms.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Therapy-Induced Senescence
Demonstrated that chemotherapy and targeted therapy can trigger tumor cell senescence, with profound implications for drug response and resistance in vivo.
RNAi Cancer Screens
Pioneered in vivo RNAi screening in mouse cancer models to identify essential genes and novel drug targets in an endogenous tumor context.
p53 and Apoptosis
Established the critical role of p53-mediated apoptosis in chemotherapy response, explaining why p53 loss confers multi-drug resistance.
Representative Works 代表性著作
Restoration of p53 function leads to tumour regression in vivo
Nature (2007)
Demonstrated that restoring p53 in established tumors causes regression, validating p53 reactivation as a therapeutic strategy.
Apoptosis and chemotherapy resistance
Science (1993)
Showed that Bcl-2 overexpression confers multidrug resistance, linking apoptosis pathways to chemosensitivity.
In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer
Nature Medicine (2011)
Used in vivo RNAi to identify FGF3/FGF4 amplification as a mechanism of sorafenib resistance in hepatocellular carcinoma.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Charles Sawyers
Memorial Sloan Kettering Cancer Center
Brian Druker
Oregon Health & Science University Knight Cancer Institute
Levi Garraway
Eli Lilly and Company / Broad Institute of MIT and Harvard
Nathanael Gray
Stanford University School of Medicine / Dana-Farber Cancer Institute
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