Martin Fassnacht
马丁·法斯纳赫特
MD
Professor and Chair of Endocrinology and Diabetology; Head, Division of Endocrinology内分泌与糖尿病学教授兼主任；内分泌部门主任
👥Biography 个人简介
Martin Fassnacht, MD is one of Europe's foremost authorities on adrenal malignancies, holding the chair of endocrinology at the University Hospital Würzburg and leading the European Network for the Study of Adrenal Tumors (ENSAT). He has defined staging systems and treatment algorithms for adrenocortical carcinoma (ACC), conducted the landmark FIRM-ACT trial evaluating mitotane-based combination chemotherapy, and led international consensus guidelines on ACC management. His research encompasses mitotane pharmacology, molecular profiling of adrenal tumors, and novel therapeutic targets in this orphan malignancy.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
FIRM-ACT Trial: Chemotherapy for Adrenocortical Carcinoma
Principal investigator of the FIRM-ACT phase III trial establishing etoposide, doxorubicin, cisplatin plus mitotane as the reference systemic regimen for advanced ACC, providing the first high-quality evidence basis for chemotherapy selection in this disease.
ENSAT Staging System for Adrenocortical Carcinoma
Led development and validation of the ENSAT staging classification for ACC, now adopted globally as the standard prognostic framework guiding surgical and adjuvant treatment decisions.
Mitotane Pharmacology and Therapeutic Drug Monitoring
Characterized mitotane pharmacokinetics, defined therapeutic blood concentration thresholds, and established monitoring protocols that optimize efficacy while minimizing toxicity in patients with ACC.
Representative Works 代表性著作
Combination Chemotherapy in Advanced Adrenocortical Carcinoma (FIRM-ACT)
New England Journal of Medicine (2012)
Phase III trial comparing EDP-mitotane versus streptozocin-mitotane in advanced ACC, establishing the reference first-line chemotherapy regimen.
European Society of Endocrinology Clinical Practice Guidelines on Adrenocortical Carcinoma
European Journal of Endocrinology (2023)
Comprehensive updated guidelines consolidating evidence for diagnosis, staging, surgery, adjuvant mitotane, and systemic therapy in ACC.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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