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cancer-genetics / cancer-geneticsBRCA1/2 and Hereditary Breast Cancer

Mark Robson

马克·罗布森

MD

🏢Memorial Sloan Kettering Cancer Center(纪念斯隆·凯特琳癌症中心)🌐USA

Chief, Breast Medicine Service乳腺医学服务主任

74
h-index
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Key Papers
3
Awards
2
Key Contributions

👥Biography 个人简介

Leading expert in BRCA-associated breast cancers at MSKCC, internationally recognized for pivotal trials of PARP inhibitors in BRCA mutation carriers. His research bridging hereditary cancer genetics and targeted therapy has transformed treatment for patients with inherited breast cancer.

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🧪Research Fields 研究领域

BRCA-related CancersBRCA相关癌症
PARP InhibitorsPARP抑制剂
Hereditary Breast Cancer遗传性乳腺癌

🎓Key Contributions 主要贡献

PARP Inhibitor Clinical Trials

Led the OlympiAD trial demonstrating olaparib superiority over chemotherapy in BRCA-mutated metastatic breast cancer, establishing PARP inhibitors as standard of care.

BRCA Cancer Management

Defined evidence-based screening, prevention, and treatment strategies for BRCA1/2 mutation carriers, incorporated into international breast cancer treatment guidelines.

Representative Works 代表性著作

[1]

Olaparib for metastatic breast cancer in patients with a germline BRCA mutation (OlympiAD)

New England Journal of Medicine (2017)

Practice-changing trial establishing olaparib as first approved PARP inhibitor for BRCA-mutated metastatic breast cancer.

[2]

BRCA1 and BRCA2 hereditary breast and ovarian cancer

New England Journal of Medicine (2016)

Comprehensive clinical review covering risk assessment, surveillance, prevention, and treatment for BRCA mutation carriers.

🏆Awards & Recognition 奖项与荣誉

🏆ASCO Distinguished Scientist Award
🏆Susan G. Komen Scientific Advisory Board Recognition
🏆MSKCC Outstanding Clinician-Scientist Award

📄Data Sources 数据来源

Last updated: 2026-01-15 | All information from publicly available academic sources

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