Marco Colonna
马可·科隆纳
MD
Robert Rock Belliveau MD Professor of Pathology; Head, Division of Immunobiology病理学罗伯特·罗克·贝利沃讲席教授；免疫生物学部门主任
👥Biography 个人简介
Marco Colonna at Washington University St. Louis is a leading figure in innate immune cell biology. He discovered DAP12, defined innate lymphoid cell (ILC) subsets, and characterized TREM receptor families, providing foundational knowledge of NK and ILC biology relevant to innate anti-tumor immunity and myeloid immunosuppression in cancer.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Discovery of DAP12 and ITAM-Based NK Signaling
Discovered DAP12, a key signaling adaptor for multiple NK cell activating receptors including NKp44 and KIR, establishing the ITAM-based signaling framework for NK cell activation and cytotoxicity against tumor targets.
Innate Lymphoid Cell Classification
Contributed foundational work classifying ILC subsets (ILC1, ILC2, ILC3) by transcriptional programs and cytokine profiles, enabling precise study of which ILC populations promote or suppress anti-tumor immunity.
TREM2 in Tumor-Associated Macrophages
Identified TREM2 as a marker of immunosuppressive tumor-associated macrophages and showed that TREM2 blockade reduces TAM immunosuppression and synergizes with anti-PD-1 to improve anti-tumor responses.
Representative Works 代表性著作
A novel family of diverse co-stimulatory receptors in humans and mice that signal through the adaptor TYROBP (DAP12)
Journal of Experimental Medicine (1999)
Discovery paper characterizing DAP12 as an ITAM-containing adaptor for a family of NK activating receptors, establishing a central signaling paradigm in innate cytotoxic immunity.
TREM2 sustains macrophage-tumor crosstalk and restricts anti-tumor immunity
Cell (2019)
Showed that TREM2+ tumor-associated macrophages are immunosuppressive and that TREM2 blockade enhances checkpoint immunotherapy responses in preclinical models.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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