Makoto Tahara
田原信
MD, PhD
Chief, Department of Head and Neck Medical Oncology头颈部肿瘤内科主任
👥Biography 个人简介
Makoto Tahara is Japan's leading head and neck cancer medical oncologist, directing the program at NCC Hospital East and conducting pivotal Asian trials for HNSCC and thyroid cancer. He led key studies on lenvatinib in head and neck cancer and thyroid malignancies, and represents Asia-Pacific perspectives in global HNSCC guideline development.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Lenvatinib in Head and Neck and Thyroid Cancers
Led multiple Asian and global trials of lenvatinib in radioiodine-refractory differentiated thyroid cancer and recurrent/metastatic HNSCC, establishing lenvatinib as a standard treatment option and elucidating predictors of response.
Asia-Pacific HNSCC Clinical Trial Leadership
Initiated and led Japanese and pan-Asian clinical trials for HNSCC immunotherapy and targeted therapy, incorporating Asian-specific epidemiology including higher proportions of hypopharyngeal and oral cavity cancers into trial design.
Representative Works 代表性著作
Lenvatinib versus placebo in radioiodine-refractory thyroid cancer (SELECT)
New England Journal of Medicine (2015)
Pivotal phase III SELECT trial demonstrating unprecedented progression-free survival improvement with lenvatinib in radioiodine-refractory differentiated thyroid cancer, gaining global regulatory approval.
Phase II study of lenvatinib in patients with recurrent or metastatic squamous cell carcinoma of the head and neck
Annals of Oncology (2022)
Demonstrated promising antitumor activity of lenvatinib monotherapy in platinum-pretreated R/M HNSCC, supporting further investigation of multi-kinase inhibition in this setting.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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University Hospital Essen (Universitätsklinikum Essen)
Suzanne George
Dana-Farber Cancer Institute / Harvard Medical School
Marcia S. Brose
Sidney Kimmel Cancer Center, Thomas Jefferson University
Lori J. Wirth
Massachusetts General Hospital, Harvard Medical School
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留下邮箱，当我们发布与 Makoto Tahara（National Cancer Center Hospital East, Chiba）相关的新研究或访谈时，我们会通知你。
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