Lin Shen
沈琳
MD, PhD
Professor, Deputy Director; Chief of GI Oncology Department教授，副院长，消化肿瘤内科主任
👥Biography 个人简介
China's foremost authority in GI oncology. Led pivotal trials of PD-1 inhibitors in gastric and esophageal cancer in China, including ORIENT-16 and RATIONALE-305. Bridging Western and Asian GI oncology practice, her work informs global understanding of immunotherapy response in Asian gastric cancer populations.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
PD-1 Immunotherapy in Chinese Gastric Cancer
Led ORIENT-16 and multiple sintilimab/tislelizumab trials in gastric cancer, demonstrating immunotherapy benefit specific to Chinese patients and informing NMPA approvals.
Biomarker Research in GI Cancers
Pioneered MSI-H, TMB, and EBV-positive subtype analyses in Chinese gastric and esophageal cancer cohorts, enabling precision immunotherapy patient selection.
Representative Works 代表性著作
Sintilimab plus chemotherapy versus chemotherapy as first-line therapy in patients with advanced or metastatic gastric or gastroesophageal junction adenocarcinoma (ORIENT-16)
The Lancet (2021)
Pivotal trial supporting NMPA approval of sintilimab for advanced gastric cancer in China.
Tislelizumab plus chemotherapy versus placebo plus chemotherapy as first-line treatment of advanced gastric or gastroesophageal junction adenocarcinoma (RATIONALE-305)
Journal of Clinical Oncology (2023)
Established tislelizumab combination as effective first-line option in gastric cancer.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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