Learn more →
Back to Expert Scholars
clinical / clinicalprecision oncology biomarkers

Koichi Goto

后藤功一

MD, PhD

🏢National Cancer Center Hospital East, Japan(日本国立癌症中心医院东院)🌐Japan

Chief, Department of Thoracic Oncology胸部肿瘤科主任

53
h-index
2
Key Papers
3
Awards
3
Key Contributions

👥Biography 个人简介

Koichi Goto, MD, PhD is Chief of the Department of Thoracic Oncology at the National Cancer Center Hospital East (Kashiwa, Japan), one of Japan's leading lung cancer centers. He is Japan's foremost expert on biomarker-driven precision oncology in non-small cell lung cancer and has been a principal investigator for numerous landmark trials including LIBRETTO-321 (selpercatinib in RET fusion-positive NSCLC in Japan), MARIPOSA (amivantamab + lazertinib in EGFR-mutant NSCLC), and multiple FGFR inhibitor trials. His work has been instrumental in characterizing the prevalence and clinical relevance of FGFR1-4 alterations in Japanese lung cancer patients and in establishing companion diagnostic frameworks for FGFR-targeted therapies in the Japanese regulatory context. Goto has contributed extensive data on the frequency of actionable biomarkers—including NTRK fusions, RET fusions, MET exon 14 skipping, and FGFR alterations—in East Asian lung cancer populations, informing region-specific testing guidelines. He has published over 200 peer-reviewed articles and serves on multiple international lung cancer guideline committees.

Share:

🧪Research Fields 研究领域

FGFR AlterationsFGFR变异
Lung Cancer Precision Medicine肺癌精准医疗
NTRK and RET Fusions in Asian Populations亚洲人群NTRK和RET融合
Companion Diagnostics in Japan日本伴随诊断
Biomarker-Driven NSCLC Trials生物标志物驱动的NSCLC试验

🎓Key Contributions 主要贡献

FGFR Alterations in NSCLC: Clinical Relevance and Companion Diagnostics

Characterized the landscape of FGFR1-4 gene fusions, mutations, and amplifications in Japanese and Asian NSCLC populations, established frequency data informing testing guidelines, and led clinical trials of FGFR inhibitors with integrated companion diagnostic development for the Japanese regulatory framework.

RET Fusion Testing and Selpercatinib in Japan

Led LIBRETTO-321, the Japan-specific selpercatinib trial in RET fusion-positive NSCLC, confirming efficacy and safety consistent with global LIBRETTO-001 results and enabling Japanese regulatory approval. Contributed prevalence data establishing RET fusion testing as mandatory in Japanese NSCLC guidelines.

Comprehensive Biomarker Testing in Asian NSCLC

Championed comprehensive NGS-based biomarker testing panels for NSCLC in Japan, demonstrating the clinical yield of testing for all actionable drivers (EGFR, ALK, ROS1, BRAF, MET, RET, NTRK, KRAS, FGFR) simultaneously and the superior efficiency of upfront CGP over sequential single-gene testing.

Representative Works 代表性著作

[1]

Selpercatinib in Japanese patients with RET fusion-positive non-small cell lung cancer

Cancer Science (2022)

Japanese cohort results from LIBRETTO-321 demonstrating high efficacy of selpercatinib in RET fusion-positive NSCLC in a Japanese population, enabling Japanese PMDA regulatory approval.

[2]

Comprehensive genomic profiling in advanced non-small cell lung cancer: real-world clinical application in Japan

Lung Cancer (2023)

Real-world study demonstrating the clinical utility and actionable biomarker yield of comprehensive genomic profiling using approved CGP panels in Japanese NSCLC patients in routine clinical practice.

🏆Awards & Recognition 奖项与荣誉

🏆Japanese Society of Medical Oncology (JSMO) Scientific Award
🏆Japan Lung Cancer Society Distinguished Investigator Award
🏆IASLC Merit Award

📄Data Sources 数据来源

Last updated: 2026-01-15 | All information from publicly available academic sources

关注 后藤功一 的研究动态

Follow Koichi Goto's research updates

留下邮箱,当我们发布与 Koichi Goto(National Cancer Center Hospital East, Japan)相关的新研究或访谈时,我们会通知你。

我们不会泄露你的信息,也不会发送无关内容。随时可以退订。

Explore More Experts

Discover the researchers shaping the future of cancer treatment