Koichi Goto
后藤功一
MD, PhD
Chief, Department of Thoracic Oncology胸部肿瘤科主任
👥Biography 个人简介
Koichi Goto, MD, PhD is Chief of the Department of Thoracic Oncology at the National Cancer Center Hospital East (Kashiwa, Japan), one of Japan's leading lung cancer centers. He is Japan's foremost expert on biomarker-driven precision oncology in non-small cell lung cancer and has been a principal investigator for numerous landmark trials including LIBRETTO-321 (selpercatinib in RET fusion-positive NSCLC in Japan), MARIPOSA (amivantamab + lazertinib in EGFR-mutant NSCLC), and multiple FGFR inhibitor trials. His work has been instrumental in characterizing the prevalence and clinical relevance of FGFR1-4 alterations in Japanese lung cancer patients and in establishing companion diagnostic frameworks for FGFR-targeted therapies in the Japanese regulatory context. Goto has contributed extensive data on the frequency of actionable biomarkers—including NTRK fusions, RET fusions, MET exon 14 skipping, and FGFR alterations—in East Asian lung cancer populations, informing region-specific testing guidelines. He has published over 200 peer-reviewed articles and serves on multiple international lung cancer guideline committees.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
FGFR Alterations in NSCLC: Clinical Relevance and Companion Diagnostics
Characterized the landscape of FGFR1-4 gene fusions, mutations, and amplifications in Japanese and Asian NSCLC populations, established frequency data informing testing guidelines, and led clinical trials of FGFR inhibitors with integrated companion diagnostic development for the Japanese regulatory framework.
RET Fusion Testing and Selpercatinib in Japan
Led LIBRETTO-321, the Japan-specific selpercatinib trial in RET fusion-positive NSCLC, confirming efficacy and safety consistent with global LIBRETTO-001 results and enabling Japanese regulatory approval. Contributed prevalence data establishing RET fusion testing as mandatory in Japanese NSCLC guidelines.
Comprehensive Biomarker Testing in Asian NSCLC
Championed comprehensive NGS-based biomarker testing panels for NSCLC in Japan, demonstrating the clinical yield of testing for all actionable drivers (EGFR, ALK, ROS1, BRAF, MET, RET, NTRK, KRAS, FGFR) simultaneously and the superior efficiency of upfront CGP over sequential single-gene testing.
Representative Works 代表性著作
Selpercatinib in Japanese patients with RET fusion-positive non-small cell lung cancer
Cancer Science (2022)
Japanese cohort results from LIBRETTO-321 demonstrating high efficacy of selpercatinib in RET fusion-positive NSCLC in a Japanese population, enabling Japanese PMDA regulatory approval.
Comprehensive genomic profiling in advanced non-small cell lung cancer: real-world clinical application in Japan
Lung Cancer (2023)
Real-world study demonstrating the clinical utility and actionable biomarker yield of comprehensive genomic profiling using approved CGP panels in Japanese NSCLC patients in routine clinical practice.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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