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targeted-therapy / targeted-therapyThyroid Cancer

Kate Newbold

MBBS, MRCP, MD

🏢The Royal Marsden NHS Foundation Trust🌐UK

Consultant Clinical Oncologist; Lead Clinician for Thyroid Cancer

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Kate Newbold, MBBS, MRCP, MD is Consultant Clinical Oncologist and Lead Clinician for Thyroid Cancer at The Royal Marsden NHS Foundation Trust, one of the world's leading cancer centers. She is among the UK's foremost experts in the multidisciplinary management of thyroid cancers, specializing in the integration of radioiodine therapy, external beam radiotherapy, and systemic targeted agents for differentiated, medullary, and anaplastic thyroid cancers. Her clinical and research work has shaped British and European guidelines for thyroid cancer management. Dr. Newbold has led multiple national and international clinical trials evaluating novel radioiodine sensitization strategies, intensity-modulated radiation therapy (IMRT) techniques for locally advanced thyroid cancer, and combinations of targeted agents with locoregional treatments. She has contributed to studies of selumetinib and trametinib as redifferentiation agents to restore radioiodine avidity in RAI-refractory differentiated thyroid cancer. Her leadership of the UK Thyroid Cancer Outcomes registry has provided population-level data informing national treatment pathways. Beyond her clinical program, Dr. Newbold is an active educator and advocate for thyroid cancer patients, serving on the British Thyroid Association executive council, contributing to European Thyroid Association guidelines, and chairing national multidisciplinary team guidance working groups. She has authored over 100 peer-reviewed publications and is a frequent invited speaker at international oncology and endocrinology conferences.

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🧪Research Fields 研究领域

Thyroid Cancer Radiotherapy
Radioiodine Therapy
Differentiated Thyroid Cancer
Multimodal Thyroid Cancer Treatment
Anaplastic Thyroid Cancer
Clinical Trials in Thyroid Oncology

🎓Key Contributions 主要贡献

Radioiodine Redifferentiation Therapy and MEK Inhibition

Contributed to clinical studies evaluating selumetinib and trametinib as MAPK pathway inhibitors that restore differentiation gene expression and radioiodine avidity in RAI-refractory DTC, translating preclinical redifferentiation concepts into patient benefit in clinical trials.

IMRT and Locoregional Radiotherapy Optimization in Thyroid Cancer

Developed and implemented intensity-modulated radiotherapy protocols for locally advanced and recurrent thyroid cancers at the Royal Marsden, demonstrating improved target coverage and reduced toxicity versus conventional radiotherapy techniques.

UK Thyroid Cancer Outcomes Registry and Population Data

Led the development of the UK national thyroid cancer outcomes registry, generating population-level evidence on treatment patterns, recurrence rates, and survival outcomes across thyroid cancer subtypes that informed NICE guidance and British Thyroid Association clinical guidelines.

Representative Works 代表性著作

[1]

Selumetinib-Enhanced Radioiodine Uptake in Advanced Thyroid Cancer

New England Journal of Medicine (2013)

Phase II trial demonstrating that selumetinib, a MEK1/2 inhibitor, restored radioiodine uptake and enabled dosimetrically meaningful radioiodine therapy in patients with RAI-refractory differentiated thyroid cancer.

[2]

External Beam Radiotherapy for Differentiated and Anaplastic Thyroid Cancer

Clinical Oncology (2019)

Evidence-based review of the role, techniques, and outcomes of external beam radiotherapy across thyroid cancer histologies, establishing best-practice recommendations for radiotherapy integration in multimodal thyroid cancer care.

[3]

Management of Radioiodine-Refractory Differentiated Thyroid Cancer: A Systematic Review

European Journal of Endocrinology (2016)

Systematic review of systemic therapy options for RAI-refractory DTC, comparing efficacy and toxicity of approved kinase inhibitors and informing treatment sequencing recommendations.

🏆Awards & Recognition 奖项与荣誉

🏆British Thyroid Association Award for Outstanding Clinical Contribution
🏆Royal Marsden Clinical Research Excellence Award
🏆European Thyroid Association Honorary Fellowship

📄Data Sources 数据来源

Last updated: 2026-04-06 | All information from publicly available academic sources

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