Karl D. Lewis
卡尔·刘易斯
MD
Professor of Medicine; Director, Cutaneous Oncology Program医学教授；皮肤肿瘤项目主任
👥Biography 个人简介
Karl Lewis is Professor of Medicine and Director of the Cutaneous Oncology Program at the University of Colorado Cancer Center. His research focuses on rare and aggressive skin malignancies, with particular expertise in Merkel cell carcinoma and other high-risk non-melanoma skin cancers. He has been instrumental in investigating checkpoint inhibitor strategies for Merkel cell carcinoma, including participation in avelumab and pembrolizumab trials that transformed the treatment paradigm for this rare but lethal neuroendocrine skin tumor.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Checkpoint Inhibition in Merkel Cell Carcinoma
Contributed to pivotal clinical trials establishing avelumab (JAVELIN Merkel 200) and pembrolizumab as effective immunotherapy options for metastatic Merkel cell carcinoma, fundamentally changing first-line systemic treatment away from cytotoxic chemotherapy.
Multidisciplinary Cutaneous Oncology
Developed comprehensive multidisciplinary tumor board protocols for rare skin cancers integrating dermatology, surgical oncology, radiation oncology, and medical oncology at a major academic cancer center.
Representative Works 代表性著作
Avelumab for Merkel-cell carcinoma: a prospective, open, multicentre trial (JAVELIN Merkel 200)
The Lancet Oncology (2022)
Updated long-term analysis of avelumab in chemotherapy-refractory and treatment-naive Merkel cell carcinoma demonstrating sustained durable responses.
Pembrolizumab as first-line therapy for advanced Merkel cell carcinoma
Journal of Clinical Oncology (2023)
Phase II data supporting pembrolizumab monotherapy as a first-line option for metastatic MCC with high objective response rates and manageable toxicity.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Carlos H. Barrios
PUCRS (Pontifical Catholic University of Rio Grande do Sul) / Hospital São Lucas, Porto Alegre, Brazil
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