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Immunotherapy / 免疫治疗Checkpoint Inhibitors

Kai W. Wucherpfennig

M.D., Ph.D.

🏢Dana-Farber Cancer Institute🌐USA

Chair, Department of Cancer Immunology and Virology

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Key Papers
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Key Contributions

👥Biography 个人简介

Kai Wucherpfennig is an expert in T cell receptor structure and function with applications to cancer immunotherapy. His research has revealed how T cell receptors recognize tumor antigens and how this recognition can be enhanced for therapy. Wucherpfennig's work on TCR-pMHC interactions informs the design of TCR-engineered T cells and bispecific T cell engagers.

Kai Wucherpfennig是T细胞受体结构和功能方面的专家,在癌症免疫治疗中有重要应用。他的研究揭示了T细胞受体如何识别肿瘤抗原以及如何增强这种识别用于治疗。Wucherpfennig在TCR-pMHC相互作用方面的工作为TCR工程化T细胞和双特异性T细胞结合器的设计提供了信息。

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🧪Research Fields 研究领域

T Cell RecognitionT细胞识别
Tumor Immunology肿瘤免疫学
Structural Immunology结构免疫学

🎓Key Contributions 主要贡献

TCR Structure

Determined structures of TCR-pMHC complexes revealing recognition mechanisms.

Tumor Antigen Recognition

Characterized T cell recognition of tumor neoantigens and self-antigens.

Representative Works 代表性著作

[1]

Structural basis of T cell recognition

Annual Review of Immunology (2010)

Comprehensive review of TCR structural biology.

📄Data Sources 数据来源

Last updated: 2026-03-04 | All information from publicly available academic sources

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