Kai W. Wucherpfennig
M.D., Ph.D.
Chair, Department of Cancer Immunology and Virology
👥Biography 个人简介
Kai Wucherpfennig is an expert in T cell receptor structure and function with applications to cancer immunotherapy. His research has revealed how T cell receptors recognize tumor antigens and how this recognition can be enhanced for therapy. Wucherpfennig's work on TCR-pMHC interactions informs the design of TCR-engineered T cells and bispecific T cell engagers.
Kai Wucherpfennig是T细胞受体结构和功能方面的专家,在癌症免疫治疗中有重要应用。他的研究揭示了T细胞受体如何识别肿瘤抗原以及如何增强这种识别用于治疗。Wucherpfennig在TCR-pMHC相互作用方面的工作为TCR工程化T细胞和双特异性T细胞结合器的设计提供了信息。
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
TCR Structure
Determined structures of TCR-pMHC complexes revealing recognition mechanisms.
Tumor Antigen Recognition
Characterized T cell recognition of tumor neoantigens and self-antigens.
Representative Works 代表性著作
Structural basis of T cell recognition
Annual Review of Immunology (2010)
Comprehensive review of TCR structural biology.
📄Data Sources 数据来源
Last updated: 2026-03-04 | All information from publicly available academic sources
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