Jessica C. Hassel
杰西卡·哈塞尔
MD
Head, Skin Cancer Center; Professor of Dermatology皮肤肿瘤中心主任；皮肤病学教授
👥Biography 个人简介
Jessica Hassel, MD is Head of the Skin Cancer Center at Heidelberg University Hospital and a leading European expert in melanoma brain metastases and uveal melanoma. She has led multiple clinical trials investigating combined immunotherapy and targeted therapy in patients with central nervous system involvement, a historically undertreated and high-mortality population. Her translational work has helped define optimal sequencing and combination strategies for intracranial metastatic melanoma.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Melanoma Brain Metastases Treatment
Led prospective trials and registry analyses characterizing outcomes with combined ipilimumab/nivolumab and BRAF-targeted therapies in active melanoma brain metastases, establishing evidence for systemic immunotherapy in this challenging population.
Uveal Melanoma Systemic Therapy
Conducted clinical research into novel agents for metastatic uveal melanoma, including tebentafusp and combined targeted/immune approaches, contributing to understanding of GNAQ/GNA11-driven biology.
Leptomeningeal Melanoma Management
Characterized clinical outcomes and potential treatment strategies for leptomeningeal disease from melanoma, one of the most challenging and rapidly fatal manifestations of CNS metastasis.
Representative Works 代表性著作
Ipilimumab alone or in combination with nivolumab in patients with melanoma metastatic to the brain
Journal of Clinical Oncology (2021)
Prospective cohort study demonstrating meaningful intracranial responses to combined checkpoint blockade in asymptomatic melanoma brain metastases.
Clinical characteristics and outcomes in patients with leptomeningeal disease from melanoma
European Journal of Cancer (2022)
Multicenter registry study defining the natural history and identifying prognostic factors in melanoma leptomeningeal metastases to guide clinical decision-making.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-20 | All information from publicly available academic sources
Related Experts 相关专家
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University of California, San Francisco (UCSF)
Maryam B. Lustberg
Yale School of Medicine / Yale Cancer Center
Sara M. Tolaney
Dana-Farber Cancer Institute / Harvard Medical School
Carlos H. Barrios
PUCRS (Pontifical Catholic University of Rio Grande do Sul) / Hospital São Lucas, Porto Alegre, Brazil
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