Jean-Pascal Machiels
让-帕斯卡·马谢尔
MD, PhD
Professor of Medical Oncology; Head, Head and Neck Oncology Program肿瘤内科学教授；头颈部肿瘤项目负责人
👥Biography 个人简介
Jean-Pascal Machiels is Belgium's foremost head and neck cancer clinical researcher at UCLouvain, known for leading the KESTREL trial of durvalumab in recurrent/metastatic HNSCC and numerous phase II/III trials investigating immunotherapy, EGFR inhibition, and novel targeted agents in HNSCC.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
KESTREL Trial and Durvalumab in HNSCC
Led the KESTREL phase III trial evaluating durvalumab with or without tremelimumab versus EXTREME chemotherapy in recurrent/metastatic HNSCC, generating key insights into dual checkpoint blockade and patient selection.
Novel Targeted Agents and Biomarker Research
Conducted numerous early- and late-phase trials of antibody-drug conjugates, PI3K inhibitors, and immune agonists in HNSCC, advancing the pipeline beyond established EGFR and PD-1 targets.
Representative Works 代表性著作
Durvalumab with or without tremelimumab in patients with recurrent or metastatic HNSCC: KESTREL, a randomized, open-label phase III study
Annals of Oncology (2022)
Phase III KESTREL trial results showing durvalumab did not significantly improve overall survival vs platinum-based therapy in unselected first-line R/M HNSCC, refining biomarker selection strategies.
Afatinib versus methotrexate as second-line treatment in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: final analysis of the randomised, open-label, phase III LUX-Head & Neck 1 trial
Annals of Oncology (2018)
Demonstrated progression-free survival benefit of afatinib over methotrexate in platinum-pretreated R/M HNSCC, establishing afatinib as a second-line option.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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