Jean-Louis Lefebvre
让-路易·勒费弗尔
MD
Professor Emeritus of Head and Neck Oncology头颈部肿瘤学荣誉教授
👥Biography 个人简介
Jean-Louis Lefebvre is a founding figure in laryngeal and hypopharyngeal cancer management and organ preservation. His landmark EORTC 24891 trial established induction chemotherapy as a viable alternative to total laryngectomy, preserving speech and quality of life for thousands of patients worldwide.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Organ Preservation
Led EORTC 24891, the first randomized trial demonstrating that sequential induction chemotherapy and radiation could preserve the larynx without compromising survival.
Hypopharyngeal Cancer
Defined optimal surgical and non-surgical management strategies for hypopharyngeal SCC, significantly improving functional outcomes and quality of life.
Representative Works 代表性著作
Larynx Preservation in Pyriform Sinus Cancer: Preliminary Results of a European Organization for Research and Treatment of Cancer Phase III Trial
Journal of the National Cancer Institute (1996)
EORTC 24891 establishing induction chemotherapy as an organ-preservation strategy for hypopharyngeal cancer.
Chemotherapy can Spare the Larynx in Patients with Piriform Sinus Carcinoma
Cancer (2004)
Long-term follow-up confirming durability of laryngeal preservation with induction chemotherapy approach.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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University of Pittsburgh Medical Center
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Cleveland Clinic Taussig Cancer Institute
Maura L. Gillison
MD Anderson Cancer Center
Kevin J. Harrington
Royal Marsden NHS Foundation Trust / Institute of Cancer Research
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