James C. Yao
姚嘉城
MD
Professor and Chair, Department of Gastrointestinal Medical Oncology胃肠肿瘤内科教授兼主任
👥Biography 个人简介
James C. Yao, MD is Professor and Chair of Gastrointestinal Medical Oncology at MD Anderson Cancer Center and one of the world's most influential investigators in neuroendocrine tumors (NETs). He was the principal investigator of the RADIANT-3 trial that established everolimus as a standard treatment for advanced pancreatic NETs and RADIANT-4, which extended its indication to non-pancreatic NETs. His research encompasses somatostatin analog biology, mTOR pathway inhibition, peptide receptor radionuclide therapy (PRRT), and novel biomarkers for NET prognosis and treatment selection.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
RADIANT-3: Everolimus in Pancreatic NETs
Led the RADIANT-3 phase III trial demonstrating that everolimus significantly extended progression-free survival in patients with advanced pancreatic NETs, establishing mTOR inhibition as a standard treatment option.
RADIANT-4: Everolimus in Non-Pancreatic NETs
Principal investigator of RADIANT-4 showing everolimus prolonged progression-free survival in patients with advanced, progressive, well-differentiated non-functional NETs of the lung or gastrointestinal tract.
NET Biomarker and Molecular Classification Development
Contributed to NETest multianalyte biomarker development and validated circulating NETest scores as tools for disease monitoring, treatment response assessment, and surveillance in NETs.
Representative Works 代表性著作
Everolimus for Advanced Pancreatic Neuroendocrine Tumors (RADIANT-3)
New England Journal of Medicine (2011)
Phase III trial establishing everolimus as an effective treatment for advanced progressive pancreatic NETs, prolonging progression-free survival by 6.4 months.
Everolimus for the Treatment of Advanced, Non-Functional Neuroendocrine Tumours of the Lung or Gastrointestinal Tract (RADIANT-4)
Lancet (2016)
Phase III randomized trial extending everolimus indication to non-pancreatic NETs, demonstrating improved PFS versus placebo.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Hope S. Rugo
University of California, San Francisco (UCSF)
Maryam B. Lustberg
Yale School of Medicine / Yale Cancer Center
Sara M. Tolaney
Dana-Farber Cancer Institute / Harvard Medical School
Carlos H. Barrios
PUCRS (Pontifical Catholic University of Rio Grande do Sul) / Hospital São Lucas, Porto Alegre, Brazil
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