James Hsieh
谢建平
MD, PhD
Associate Attending Physician; Associate Member, Human Oncology and Pathogenesis Program副主治医师；人类肿瘤学与发病机制项目副研究员
👥Biography 个人简介
James Hsieh is a leading physician-scientist at MSKCC specializing in the molecular genetics of renal cell carcinoma. His landmark work decoding VHL pathway biology, chromatin remodeling gene mutations, and intratumoral heterogeneity in RCC has informed therapeutic targeting strategies.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
VHL and Chromatin Remodeling Genes in RCC
Elucidated roles of VHL and chromatin remodeling genes (PBRM1, SETD2, BAP1) in clear cell RCC biology and their impact on prognosis, intratumoral heterogeneity, and treatment response.
Intratumoral Heterogeneity in Kidney Cancer
Contributed to TRACERx Renal studies mapping clonal evolution and intratumoral genetic heterogeneity in RCC, revealing mechanisms of immune evasion and therapeutic resistance.
Representative Works 代表性著作
Multiregion Sequencing Reveals the Intratumoral Heterogeneity of Clear Cell Renal Cell Carcinoma
Nature Genetics (2012)
Demonstrated extensive intratumoral genetic heterogeneity in ccRCC driven by branched clonal evolution, explaining challenges in biomarker development and targeted therapy.
SETD2 Loss of Function Promotes Renal Cancer Branched Evolution through Replication Stress
Cancer Cell (2017)
Showed SETD2 mutations drive branched evolution in RCC via replication stress, revealing a key mechanism of intratumoral heterogeneity and drug resistance.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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Memorial Sloan Kettering Cancer Center
Jonathan Rosenberg
Memorial Sloan Kettering Cancer Center
Thomas Powles
Barts Cancer Institute, Queen Mary University of London
Andrea Necchi
Vita-Salute San Raffaele University
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