Andrea Necchi
安德烈亚·内基
MD
Professor of Medical Oncology; Head, Genitourinary Oncology Program医学肿瘤学教授；泌尿肿瘤项目负责人
👥Biography 个人简介
Andrea Necchi is a globally recognized bladder cancer specialist pioneering neoadjuvant therapy and biomarker-driven approaches. His research on perioperative immunotherapy and FGFR-targeted therapy in muscle-invasive bladder cancer has transformed surgical management strategies.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Neoadjuvant Immunotherapy in Muscle-Invasive Bladder Cancer
Conducted pivotal studies of neoadjuvant pembrolizumab and other checkpoint inhibitors prior to radical cystectomy, establishing pathologic complete response as a key endpoint.
FGFR3 Targeted Therapy
Led research into erdafitinib and other FGFR inhibitors in FGFR3-altered urothelial carcinoma, advancing precision medicine approaches for molecularly selected patients.
Representative Works 代表性著作
Pembrolizumab as Neoadjuvant Therapy Before Radical Cystectomy in Muscle-Invasive Urothelial Bladder Carcinoma
Journal of Clinical Oncology (2018)
PURE-01 trial demonstrating feasibility and activity of neoadjuvant pembrolizumab in MIBC, with high pathologic response rates correlating with PD-L1 expression.
Erdafitinib in Locally Advanced or Metastatic Urothelial Carcinoma
New England Journal of Medicine (2019)
Demonstrated erdafitinib activity in FGFR3/2-altered urothelial carcinoma, leading to first FDA-approved targeted therapy for a genomically defined bladder cancer subset.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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