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clinical / clinicalsupportive care

Hiroko Watanabe

渡边裕子

MD, PhD

🏢National Cancer Center Hospital, Tokyo(国立癌研究中心医院,东京)🌐Japan

Chief, Department of Palliative Medicine; Associate Professor, Division of Supportive and Palliative Care姑息医学科科长;支持与姑息治疗部副教授

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Hiroko Watanabe, MD, PhD is Chief of the Department of Palliative Medicine at the National Cancer Center Hospital in Tokyo and a leading authority on bone metastases management and hospice utilization in Japan. She has led multicenter prospective studies comparing denosumab and zoledronic acid for skeletal-related event prevention across breast, lung, and prostate cancer populations in Japanese patients, contributing to Japan-specific dosing and safety data. Dr. Watanabe is a principal investigator in the Japan Clinical Oncology Group (JCOG) palliative care working group and has authored national guidelines for palliative radiotherapy in bone metastases, including evidence-based recommendations for single-fraction versus multi-fraction approaches. Her public health research has examined barriers to hospice and palliative care enrollment in Japan's rapidly aging cancer population and has contributed to national policy reform expanding access to community-based palliative services. She has published over 130 papers and is a sought-after speaker at ASCO, ESMO, and the Japanese Society of Medical Oncology.

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🧪Research Fields 研究领域

Bone Metastases Management骨转移管理
Denosumab and Zoledronic Acid地诺单抗与唑来膦酸
Palliative Radiotherapy姑息性放疗
Hospice Utilization Japan日本临终关怀利用
Skeletal-Related Events Prevention骨相关事件预防

🎓Key Contributions 主要贡献

Denosumab vs. Zoledronic Acid in Japanese Cancer Patients

Led multicenter prospective studies in Japan comparing denosumab and zoledronic acid for skeletal-related event prevention in bone-metastatic breast, lung, and prostate cancers, generating ethnicity-specific safety and efficacy data.

Palliative Radiotherapy Guidelines for Bone Metastases

Developed and disseminated national Japanese Society of Radiation Oncology guidelines endorsing single-fraction palliative radiotherapy as equivalent to multifraction regimens for uncomplicated bone metastases, improving access and reducing treatment burden.

Hospice Access and End-of-Life Policy in Japan

Conducted national surveys and policy analyses identifying structural barriers to hospice and palliative care utilization in Japan's aging cancer population, contributing to regulatory and reimbursement reforms expanding palliative services.

Representative Works 代表性著作

[1]

Denosumab Versus Zoledronic Acid in Japanese Patients with Bone Metastases from Breast Cancer

Breast Cancer (2020)

Multicenter prospective Japanese cohort study demonstrating comparable skeletal-related event prevention between denosumab and zoledronic acid, with denosumab showing favorable osteonecrosis of the jaw profile.

[2]

Single-Fraction Palliative Radiotherapy for Bone Metastases: Real-World Outcomes in Japan

Japanese Journal of Clinical Oncology (2022)

Large retrospective study confirming efficacy and tolerability of single-fraction 8 Gy palliative radiotherapy for uncomplicated bone metastases in Japanese cancer patients.

🏆Awards & Recognition 奖项与荣誉

🏆Japanese Society of Medical Oncology Young Investigator Award
🏆JCOG Palliative Care Research Excellence Prize
🏆National Cancer Center Hospital Outstanding Research Award

📄Data Sources 数据来源

Last updated: 2026-01-20 | All information from publicly available academic sources

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