Gregory S. Weinstein
格雷戈里·温斯坦
MD, FACS
Professor and Vice Chairman, Department of Otorhinolaryngology–Head and Neck Surgery; Director, Division of Head and Neck Surgery耳鼻咽喉头颈外科系教授兼副主任;头颈外科部门主任
👥Biography 个人简介
Gregory S. Weinstein, MD, FACS is Professor and Vice Chairman of Otorhinolaryngology–Head and Neck Surgery at the University of Pennsylvania Perelman School of Medicine, where he directs the Division of Head and Neck Surgery. He is internationally recognized as one of the co-inventors and most influential clinical champions of Transoral Robotic Surgery (TORS), a minimally invasive surgical approach that revolutionized organ preservation in oropharyngeal and hypopharyngeal cancers. Together with Bert O'Malley Jr., Dr. Weinstein developed and led the clinical validation studies of TORS using the da Vinci Surgical System, demonstrating that robotic-assisted transoral resection could achieve excellent oncologic outcomes with dramatically reduced morbidity compared with open surgery or even total laryngectomy. Their work culminated in FDA clearance of TORS in 2009 and has since enabled de-escalation of adjuvant radiotherapy in selected HPV-positive OPSCC patients undergoing upfront surgical resection. Dr. Weinstein has authored over 300 peer-reviewed publications and has trained hundreds of head and neck surgeons in TORS worldwide.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Co-invention and Clinical Validation of Transoral Robotic Surgery (TORS)
Co-developed TORS with Bert O'Malley Jr., leading the first clinical feasibility studies in humans and demonstrating safety and oncologic adequacy of da Vinci robotic-assisted transoral resection for oropharyngeal and supraglottic cancers, leading to FDA clearance in 2009.
TORS for HPV-Positive Oropharyngeal Cancer De-escalation
Led and contributed to clinical studies demonstrating that TORS can enable de-escalation of adjuvant treatment in early-stage HPV-positive OPSCC, reducing radiotherapy dose and chemotherapy use for surgical complete resection patients and minimizing long-term swallowing and xerostomia toxicity.
Organ Preservation in Hypopharynx Cancer
Conducted pioneering work using supracricoid laryngectomy and TORS-based resection to preserve laryngeal function in selected hypopharyngeal and supraglottic carcinoma patients who otherwise would have undergone total laryngectomy, establishing key criteria for patient selection and surgical technique.
TORS Training and Global Dissemination
Founded and directed comprehensive TORS training programs at Penn Medicine attracting surgeons from over 40 countries, standardizing operative techniques, safety protocols, and resident training curricula that have established Penn as the global center of excellence for TORS education.
Representative Works 代表性著作
Transoral robotic surgery: supraglottic partial laryngectomy
Annals of Otology, Rhinology and Laryngology (2007)
First clinical report of TORS for supraglottic laryngectomy, establishing feasibility and describing surgical technique with early functional outcomes in laryngeal cancer patients.
Transoral robotic surgery for oropharyngeal carcinomas
Archives of Otolaryngology–Head and Neck Surgery (2010)
Early outcomes study of TORS for T1-T2 oropharyngeal carcinoma demonstrating high negative margin rates, low morbidity, and rapid return to swallowing, supporting TORS as an alternative to primary chemoradiotherapy.
De-escalation of adjuvant treatment after TORS for HPV-positive oropharyngeal cancer: a multi-institutional study
Head & Neck (2021)
Multi-institutional analysis showing that TORS-based primary surgery allows de-escalation of adjuvant radiotherapy from 60–66 Gy to 50 Gy in pathologically low-risk HPV-positive OPSCC with maintained oncologic control.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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