Katy Rezvani
凯蒂·雷兹瓦尼
MD, PhD
Professor and Section Chief, Cellular Therapy; Deputy Chair, Stem Cell Transplantation细胞治疗科主任，干细胞移植副主席
👥Biography 个人简介
Katy Rezvani is a leading pioneer in CAR-NK cell therapy, having conducted one of the first clinical trials of cord-blood-derived, CAR-expressing NK cells targeting CD19 in patients with lymphoid malignancies. Her work at MD Anderson demonstrated remarkable clinical responses with an off-the-shelf NK cell product, establishing CAR-NK therapy as a viable alternative to CAR-T with a distinct safety profile and manufacturing advantages.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
First-in-Human CAR-NK Trial
Led the landmark Phase I/II trial of CD19-directed cord blood CAR-NK cells in relapsed/refractory CLL and lymphoma, showing 73% overall response rate without CRS or neurotoxicity.
Off-the-Shelf NK Manufacturing
Developed scalable GMP protocols for allogeneic cord blood NK cell expansion and genetic engineering, enabling multi-patient dosing from single donors.
NK Cell Persistence Strategies
Engineered IL-15-secreting CAR-NK cells to overcome the limitation of poor NK cell persistence in vivo, significantly extending therapeutic duration.
Representative Works 代表性著作
Anti-CD19 CAR NK cells from cord blood for treatment of relapsed and refractory B-cell lymphoid tumors
New England Journal of Medicine (2020)
First report of clinical efficacy of cord blood-derived CAR-NK cells, demonstrating 73% response rate in heavily pre-treated patients with no dose-limiting toxicities.
Cytokine engineering of NK cells for cancer immunotherapy
Nature Reviews Cancer (2023)
Comprehensive review of cytokine armoring strategies (IL-15, IL-21) to enhance CAR-NK cell persistence, metabolic fitness, and anti-tumor efficacy.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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University of California, San Francisco (UCSF)
Maryam B. Lustberg
Yale School of Medicine / Yale Cancer Center
Sara M. Tolaney
Dana-Farber Cancer Institute / Harvard Medical School
Carlos H. Barrios
PUCRS (Pontifical Catholic University of Rio Grande do Sul) / Hospital São Lucas, Porto Alegre, Brazil
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