Giles Robinson
贾尔斯·鲁滨逊
MD
Associate Member, Department of Oncology; Director, Medulloblastoma Program肿瘤学系副研究员；髓母细胞瘤项目主任
👥Biography 个人简介
Giles Robinson is a leading pediatric oncologist at St. Jude specializing in medulloblastoma clinical trials, who pioneered vismodegib and sonidegib SHH inhibitor studies in pediatric SHH-medulloblastoma and leads risk-stratified treatment reduction trials to minimize long-term toxicity in favorable-risk patients.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
SHH Inhibitor Clinical Trials
Led phase I/II trials of vismodegib and sonidegib in pediatric SHH-medulloblastoma, defining pharmacokinetics, toxicity profiles, and efficacy in this molecularly defined subgroup.
Risk-Adapted Therapy Reduction
Leads SJMB12 and related St. Jude trials testing reduced-dose radiotherapy and chemotherapy in low-risk medulloblastoma to preserve neurocognitive outcomes without sacrificing survival.
Molecular Subgroup-Guided Treatment
Established molecular subgroup assignment as a clinical standard at St. Jude, enabling prospective subgroup-specific treatment allocation in newly diagnosed medulloblastoma.
Representative Works 代表性著作
Vismodegib exerts targeted efficacy against recurrent Sonic Hedgehog-subgroup medulloblastoma
Journal of Clinical Oncology (2015)
Demonstrated targeted clinical activity of vismodegib in SHH-medulloblastoma, supporting molecularly guided treatment.
Risk-adapted craniospinal irradiation in pediatric medulloblastoma: SJMB12 trial
Lancet Oncology (2022)
Landmark trial demonstrating safety of reduced-dose craniospinal irradiation in favorable-risk medulloblastoma subgroups.
Molecular subgroups of medulloblastoma: the current consensus
Acta Neuropathologica (2020)
International consensus statement on medulloblastoma molecular subgroups and their clinical implications for therapy.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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