Franziska Michor
弗朗西斯卡·米霍尔
PhD
Professor of Computational Biology计算生物学教授
👥Biography 个人简介
Mathematical oncologist who applies evolutionary dynamics and quantitative modeling to understand cancer initiation, progression, and treatment resistance. Her models of CML response to imatinib became a landmark in precision oncology.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
CML Evolutionary Dynamics
Developed mathematical models of CML response to imatinib that predicted resistance emergence and optimal treatment strategies, validated in clinical cohorts.
Cancer Evolution Modeling
Created frameworks for modeling cancer initiation and progression based on evolutionary theory, quantifying rates of driver mutation accumulation.
Combination Therapy Optimization
Designed mathematical approaches to optimize drug combination timing and sequencing to prevent resistance, directly informing clinical trial design.
Representative Works 代表性著作
Dynamics of chronic myeloid leukaemia
Nature (2005)
Mathematical model of CML under imatinib predicting kinetics of treatment response and conditions for resistance emergence.
Evolution of resistance to targeted anti-cancer therapies during continuous and pulsed administration strategies
PLoS Computational Biology (2010)
Quantitative models showing pulsed dosing strategies can delay resistance compared to continuous dosing.
Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition
Nature Communications (2017)
Combined genomics and modeling to track CLL clonal evolution under ibrutinib therapy.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Mary-Claire King
University of Washington
Kenneth Offit
Memorial Sloan Kettering Cancer Center
Judy Garber
Dana-Farber Cancer Institute
Barbara Biesecker
RTI International / NHGRI
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留下邮箱，当我们发布与 Franziska Michor（Dana-Farber Cancer Institute / Harvard T.H. Chan School of Public Health）相关的新研究或访谈时，我们会通知你。
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