Florent Ginhoux
弗洛朗·吉努
PhD
Senior Principal Investigator; Head, Myeloid Cell Biology Lab高级首席研究员；髓系细胞生物学实验室主任
👥Biography 个人简介
Florent Ginhoux at SIgN A*STAR Singapore is a global leader in myeloid cell biology and tumor macrophage differentiation. He discovered the embryonic origin of microglia from yolk-sac precursors and has extensively mapped TAM ontogeny and differentiation trajectories using single-cell multiomics, transforming understanding of tumor-promoting myeloid programs.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Yolk-Sac Origin of Microglia
Demonstrated through fate-mapping that brain microglia derive exclusively from yolk-sac primitive macrophage precursors and not from adult bone marrow, establishing the paradigm of tissue macrophage ontogeny now applied to tumor-resident macrophages.
TAM Ontogeny and Differentiation Trajectories
Used single-cell RNA-seq and lineage tracing to define the differentiation trajectories of tumor-associated macrophages arising from both tissue-resident and monocyte-derived precursors, revealing how ontogeny determines TAM functional state.
Myeloid Diversity Atlas in Human Tumors
Built comprehensive single-cell transcriptomic and epigenomic atlases of myeloid cells across multiple human tumor types, identifying conserved immunosuppressive TAM states and novel targets for myeloid reprogramming in immuno-oncology.
Representative Works 代表性著作
Fate mapping analysis reveals that adult microglia derive from primitive macrophages
Science (2010)
Landmark fate-mapping study demonstrating yolk-sac origin of microglia, overturning the dogma of monocyte-derived brain macrophages and founding the tissue macrophage ontogeny field.
A clonogenic bone marrow progenitor specific for macrophages and dendritic cells
Science (2006)
Identified the macrophage-DC progenitor (MDP) in bone marrow as the common upstream precursor for circulating monocytes and DCs, clarifying myeloid progenitor hierarchy relevant to TAM replenishment.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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留下邮箱，当我们发布与 Florent Ginhoux（Singapore Immunology Network (SIgN), A*STAR）相关的新研究或访谈时，我们会通知你。
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