Ezra E.W. Cohen
以斯拉·科恩
MD, FRCPSC, FACP
Associate Director for Translational Science; Professor of Medicine转化科学副主任；医学教授
👥Biography 个人简介
Ezra Cohen is a leading expert in molecularly targeted therapies and immunotherapy for head and neck cancers. He has led numerous pivotal trials of EGFR inhibitors, immune checkpoint inhibitors, and novel agents in HNSCC and thyroid cancer, contributing to multiple FDA approvals.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
EGFR-Targeted Therapy
Led early and pivotal trials of afatinib and other EGFR pathway inhibitors in HNSCC, defining the role of targeted therapy in this disease.
Immunotherapy Development
Co-led KEYNOTE-012 and subsequent trials establishing pembrolizumab activity in HNSCC, helping pave the way for FDA approval.
Representative Works 代表性著作
Afatinib versus Methotrexate as Second-Line Treatment in Patients with Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck
Lancet Oncology (2014)
LUX-Head & Neck 1 trial establishing afatinib as a standard second-line option in HNSCC.
Pembrolizumab versus Methotrexate, Docetaxel, or Cetuximab for Recurrent or Metastatic Head-and-Neck Squamous Cell Carcinoma
Lancet (2019)
KEYNOTE-040 supporting pembrolizumab's role in recurrent/metastatic HNSCC.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Robert L. Ferris
University of Pittsburgh Medical Center
David J. Adelstein
Cleveland Clinic Taussig Cancer Institute
Maura L. Gillison
MD Anderson Cancer Center
Kevin J. Harrington
Royal Marsden NHS Foundation Trust / Institute of Cancer Research
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