Eva Dombi
伊娃·多姆比
MD
Physician-Scientist, Pediatric Oncology Branch儿科肿瘤分部医学科学家
👥Biography 个人简介
Dr. Dombi is a key clinical investigator at NCI's Pediatric Oncology Branch specializing in NF1 clinical trials and imaging response assessment. She developed volumetric MRI methodologies for plexiform neurofibroma response evaluation and contributed critically to the SPRINT selumetinib trial.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Volumetric MRI Response Assessment
Developed and validated volumetric MRI techniques for measuring plexiform neurofibroma response in NF1 clinical trials, establishing standardized endpoints now used in NF1 trials worldwide.
NF1 Natural History Studies
Contributed to defining natural history of plexiform neurofibromas through longitudinal imaging studies, identifying growth patterns and risk factors that inform clinical trial eligibility and treatment decisions.
Representative Works 代表性著作
Activity of Selumetinib in Neurofibromatosis Type 1-Related Plexiform Neurofibromas
New England Journal of Medicine (2016)
Phase II trial establishing selumetinib activity in NF1 plexiform neurofibromas, demonstrating tumor shrinkage and clinical benefit in the pivotal lead-in study preceding SPRINT.
Volumetric MRI and Functional Outcome in Plexiform Neurofibroma Clinical Trials
Neurology (2018)
Validated volumetric MRI as a reliable endpoint for NF1 plexiform neurofibroma trials, correlating imaging response with functional improvements and quality of life measures.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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