Eric Bouffet
埃里克·布费
MD, FRCP(C)
Division Head, Haematology/Oncology; Garron Family Chair in Childhood Cancer Research血液肿瘤科主任；儿童癌症研究Garron家族讲席教授
👥Biography 个人简介
Eric Bouffet is a globally renowned pediatric neuro-oncologist at SickKids Toronto who has led pivotal DIPG and pediatric CNS tumor trials for decades, championed BRAF-targeted therapy for pediatric gliomas, and established international collaborative frameworks advancing treatment for children with brain tumors.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
DIPG Clinical Trials Leadership
Led and co-led multiple international phase I/II trials in DIPG including ONC201, convection-enhanced delivery, and combination immunotherapy approaches, advancing the clinical evidence base.
BRAF-Targeted Therapy in Pediatric Glioma
Pioneered use of vemurafenib and dabrafenib/trametinib in BRAF V600E-mutant pediatric gliomas through early-phase trials, establishing targeted therapy as standard of care.
International Pediatric Neuro-Oncology Collaboration
Co-founded and led SIOPE's Brain Tumour Group and Pacific Pediatric Neuro-Oncology Consortium (PNOC), enabling multi-continental trials in rare pediatric brain tumors.
Representative Works 代表性著作
Vemurafenib in pediatric patients with BRAFV600E mutated high-grade gliomas
European Journal of Cancer (2018)
Demonstrated clinical activity of BRAF inhibition in pediatric high-grade glioma, supporting targeted therapy approaches.
Immunotherapy in pediatric brain tumors: past, present, and future
Neuro-Oncology (2021)
Comprehensive review of immunotherapy landscape in pediatric CNS tumors, outlining rational combination strategies.
ONC201 for H3K27M-mutant pediatric diffuse midline glioma after radiotherapy
Nature Medicine (2023)
Multi-center study demonstrating ONC201 efficacy and tolerability in H3K27M-mutant DMG patients post-irradiation.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Carlos H. Barrios
PUCRS (Pontifical Catholic University of Rio Grande do Sul) / Hospital São Lucas, Porto Alegre, Brazil
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留下邮箱，当我们发布与 Eric Bouffet（The Hospital for Sick Children (SickKids), University of Toronto）相关的新研究或访谈时，我们会通知你。
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