Elena Garralda
埃莱娜·加拉尔达
MD, PhD
Head, Early Clinical Drug Development; Principal Investigator, Molecular Therapeutics Research Unit早期临床药物开发主任；分子治疗学研究室首席研究员
👥Biography 个人简介
Europe's preeminent early-phase oncology trialist, leading first-in-human and Phase I studies of novel anticancer agents at VHIO. Specialist in molecularly matched trial design and innovative biomarker-driven dose-escalation strategies for immunotherapy and targeted agents.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
First-in-Human Trial Design
Led design and execution of 50+ Phase I first-in-human oncology trials, incorporating adaptive dose escalation and pharmacodynamic biomarker endpoints.
Molecularly Matched Clinical Development
Pioneered biomarker-selected patient enrichment in early oncology trials, improving signal detection and accelerating proof-of-concept for novel agents.
Immunotherapy-Targeted Combination Trials
Designed innovative early-phase combination trials integrating immunotherapy with targeted agents, establishing rational dosing and safety frameworks.
Representative Works 代表性著作
Antitumor activity of the MDM2 inhibitor BI-907828 in solid tumors: first-in-human Phase I study
Cancer Discovery (2022)
Led first-in-human study of MDM2 inhibitor demonstrating early efficacy signals in TP53 wild-type tumors.
Phase I study of the FGFR inhibitor infigratinib in patients with advanced solid tumors
Clinical Cancer Research (2019)
Early-phase study establishing recommended dose and identifying FGFR-altered tumors as responders to infigratinib.
Clinical activity of atezolizumab in patients with metastatic urothelial carcinoma
Journal of Clinical Oncology (2017)
Contributed to pivotal early-phase data supporting atezolizumab approval in bladder cancer.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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留下邮箱，当我们发布与 Elena Garralda（Vall d'Hebron Institute of Oncology (VHIO)）相关的新研究或访谈时，我们会通知你。
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