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Eduardo Bruera

爱德华多·布鲁拉

MD

🏢The University of Texas MD Anderson Cancer Center(德克萨斯大学MD安德森癌症中心)🌐USA

F.T. McGraw Chair in the Treatment of Cancer; Professor and Chair, Department of Palliative, Rehabilitation and Integrative Medicine癌症治疗麦格劳讲席教授;姑息、康复与整合医学系主任

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Eduardo Bruera, MD is F.T. McGraw Chair in the Treatment of Cancer and Professor and Chair of the Department of Palliative, Rehabilitation and Integrative Medicine at MD Anderson Cancer Center. Born in Argentina and trained across South America and Canada, Dr. Bruera is widely regarded as one of the founding fathers of modern palliative medicine as an academic discipline. He has conducted over 200 randomized clinical trials addressing the most challenging clinical problems in advanced cancer: opioid rotation, delirium, dyspnea, fatigue, cachexia, and goals-of-care communication. His work on opioid pharmacology — including rotation strategies to manage tolerance, hyperalgesia, and neurotoxicity — has become standard oncology practice globally. Dr. Bruera has championed the use of palliative care outpatient clinics embedded within cancer centers and has published foundational trials on early consultation, advance care planning conversations, and the Edmonton Symptom Assessment System (ESAS), the most widely used multi-symptom assessment tool in palliative oncology. He has authored over 700 peer-reviewed publications, supervised over 200 palliative care fellows, and received honorary degrees from six universities worldwide.

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🧪Research Fields 研究领域

Palliative Medicine姑息医学
Opioid Rotation and Dose Titration阿片类药物轮换与剂量滴定
Delirium at End of Life临终期谵妄
Advance Care Planning预先护理计划
Cachexia and Anamorelin恶病质与阿那莫林

🎓Key Contributions 主要贡献

Opioid Rotation and Titration in Cancer Pain

Established the clinical evidence base for opioid rotation as a strategy to manage opioid tolerance, neurotoxicity, and inadequate analgesia, and conducted randomized trials comparing equianalgesic dosing regimens that now underpin international cancer pain guidelines.

Edmonton Symptom Assessment System

Co-developed the Edmonton Symptom Assessment System (ESAS), the most widely used validated multi-symptom assessment tool in palliative oncology, now implemented in cancer centers across more than 40 countries and integrated into electronic health records.

Advance Care Planning and Goals of Care Conversations

Led randomized trials evaluating structured advance care planning interventions and family conference protocols in advanced cancer, demonstrating improvements in patient goal concordance, reduction of aggressive end-of-life care, and caregiver bereavement outcomes.

Cancer Cachexia: Anamorelin Trials

Conducted foundational clinical trials of anamorelin (a ghrelin receptor agonist) for cancer cachexia-anorexia syndrome in NSCLC, contributing to the evidence base that led to its regulatory approval in Japan and ongoing evaluation in Western markets.

Representative Works 代表性著作

[1]

Opioid Rotation in Patients with Cancer Pain: A Systematic Review of Randomized Trials and Observational Studies

Journal of Clinical Oncology (2018)

Comprehensive systematic review establishing evidence-based recommendations for opioid rotation protocols in cancer pain management.

[2]

Anamorelin in Patients with Non-Small-Cell Lung Cancer and Cachexia: A Randomized Phase 2 Trial

Lancet Oncology (2015)

Phase II randomized trial demonstrating anamorelin's ability to increase lean body mass, body weight, and appetite scores in NSCLC patients with cachexia.

🏆Awards & Recognition 奖项与荣誉

🏆ASCO Palliative Care in Oncology Symposium Lifetime Achievement Award
🏆American Academy of Hospice and Palliative Medicine Clinician of the Year
🏆International Association for Hospice and Palliative Care Lifetime Award
🏆Honorary Degrees from University of Buenos Aires, University of Alberta, and four other institutions

📄Data Sources 数据来源

Last updated: 2026-01-20 | All information from publicly available academic sources

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