Dana Pe'er
达娜·佩尔
PhD
Chair, Computational and Systems Biology Program计算与系统生物学项目主任
👥Biography 个人简介
Pioneering computational biologist who has transformed understanding of tumor heterogeneity through single-cell genomics. Her algorithms for trajectory analysis and cell state identification are widely used in cancer research globally.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Single-Cell Analysis Algorithms
Developed Wishbone and Palantir algorithms for pseudotime trajectory analysis, enabling reconstruction of cancer cell differentiation and progression from single-cell data.
Tumor Microenvironment Dissection
Used single-cell RNA-seq to systematically dissect the tumor microenvironment across cancer types, revealing immune evasion mechanisms and therapeutic targets.
Cancer Cell State Mapping
Created comprehensive single-cell atlases of cancer cell states, identifying stem-like and therapy-resistant populations that drive recurrence.
Representative Works 代表性著作
Wishbone identifies bifurcating developmental trajectories from single-cell data
Nature Biotechnology (2016)
Introduced trajectory analysis method enabling reconstruction of developmental lineages from single-cell genomics data.
A dissection of the multicellular ecosystem for advanced human ovarian cancer
Nature Genetics (2020)
Single-cell characterization of ovarian cancer ecosystem revealing tumor microenvironment architecture and therapeutic vulnerabilities.
Characterizing transcriptional heterogeneity through pathway and gene set overdispersion analysis
Nature Methods (2016)
Developed PAGODA method for identifying transcriptional heterogeneity patterns in single-cell cancer data.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Mary-Claire King
University of Washington
Kenneth Offit
Memorial Sloan Kettering Cancer Center
Judy Garber
Dana-Farber Cancer Institute
Barbara Biesecker
RTI International / NHGRI
关注 达娜·佩尔 的研究动态
Follow Dana Pe'er's research updates
留下邮箱，当我们发布与 Dana Pe'er（Memorial Sloan Kettering Cancer Center）相关的新研究或访谈时，我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment