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Andreas Hilpert

安德烈亚斯·希尔珀特

MD, PhD

🏢University Medical Center Hamburg-Eppendorf(汉堡-埃彭多夫大学医学中心)🌐Germany

Professor of Neurology; Head, Chemotherapy-Induced Neuropathy Research Unit神经病学教授;化疗诱导神经病变研究部门负责人

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Andreas Hilpert, MD, PhD is Professor of Neurology and Head of the Chemotherapy-Induced Neuropathy Research Unit at the University Medical Center Hamburg-Eppendorf. A leading European authority on chemotherapy-induced peripheral neuropathy (CIPN), Professor Hilpert has led multicenter trials evaluating preventive strategies for taxane- and platinum-induced neuropathy, and has developed standardized electrophysiological and patient-reported outcome assessment protocols that are used in investigational neurotoxicity studies across Germany, Austria, and Switzerland. He contributed to the validation of the European Organisation for Research and Treatment of Cancer (EORTC) CIPN-20 questionnaire and has published seminal mechanistic studies on the pathophysiology of oxaliplatin-induced neuropathy, including cold allodynia and chronic sensory loss. His research on duloxetine as a treatment for established CIPN, informed by ALLIANCE A221201 trial data, has contributed to current ASCO guideline recommendations. Professor Hilpert is an active member of the MASCC Neurological Complications study group.

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🧪Research Fields 研究领域

Chemotherapy-Induced Peripheral Neuropathy化疗诱导的周围神经病变
CIPN Assessment and GradingCIPN评估与分级
Neurotoxicity Prevention神经毒性预防
Duloxetine for CIPN度洛西汀治疗CIPN
Patient-Reported Neuropathy Outcomes患者报告神经病变结局

🎓Key Contributions 主要贡献

CIPN Assessment Tools and Electrophysiology

Developed standardized neurophysiological assessment batteries and contributed to validation of the EORTC CIPN-20 patient-reported outcome questionnaire, enabling systematic tracking of sensory, motor, and autonomic neuropathy severity in clinical trials.

Oxaliplatin-Induced Peripheral Neuropathy Mechanisms

Conducted mechanistic studies elucidating the pathophysiology of oxaliplatin-induced acute neuropathy (cold allodynia via Nav channel modulation) and chronic sensory neuropathy, informing rational design of neuroprotective interventions.

Pharmacological Management of Established CIPN

Contributed clinical evidence supporting duloxetine and SNRIs for established paclitaxel- and oxaliplatin-induced peripheral neuropathy, consistent with ASCO guideline moderate-evidence recommendations.

Representative Works 代表性著作

[1]

Oxaliplatin-Induced Peripheral Neuropathy: Pathomechanisms and Clinical Management

Nature Reviews Neurology (2019)

Comprehensive mechanistic and clinical review of oxaliplatin neuropathy, covering acute and chronic forms, electrophysiology, biomarkers, and therapeutic options.

[2]

Validation of the EORTC QLQ-CIPN20 in Patients Receiving Neurotoxic Chemotherapy

European Journal of Cancer (2015)

Multicenter psychometric validation of the EORTC CIPN-20 patient-reported outcome questionnaire, establishing its reliability and responsiveness across chemotherapy regimens.

🏆Awards & Recognition 奖项与荣誉

🏆German Cancer Society Supportive Care Research Award
🏆MASCC Young Investigator Award (Early Career)
🏆University Hamburg Excellence in Research Prize

📄Data Sources 数据来源

Last updated: 2026-01-20 | All information from publicly available academic sources

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