Andreas Hilpert
安德烈亚斯·希尔珀特
MD, PhD
Professor of Neurology; Head, Chemotherapy-Induced Neuropathy Research Unit神经病学教授;化疗诱导神经病变研究部门负责人
👥Biography 个人简介
Andreas Hilpert, MD, PhD is Professor of Neurology and Head of the Chemotherapy-Induced Neuropathy Research Unit at the University Medical Center Hamburg-Eppendorf. A leading European authority on chemotherapy-induced peripheral neuropathy (CIPN), Professor Hilpert has led multicenter trials evaluating preventive strategies for taxane- and platinum-induced neuropathy, and has developed standardized electrophysiological and patient-reported outcome assessment protocols that are used in investigational neurotoxicity studies across Germany, Austria, and Switzerland. He contributed to the validation of the European Organisation for Research and Treatment of Cancer (EORTC) CIPN-20 questionnaire and has published seminal mechanistic studies on the pathophysiology of oxaliplatin-induced neuropathy, including cold allodynia and chronic sensory loss. His research on duloxetine as a treatment for established CIPN, informed by ALLIANCE A221201 trial data, has contributed to current ASCO guideline recommendations. Professor Hilpert is an active member of the MASCC Neurological Complications study group.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
CIPN Assessment Tools and Electrophysiology
Developed standardized neurophysiological assessment batteries and contributed to validation of the EORTC CIPN-20 patient-reported outcome questionnaire, enabling systematic tracking of sensory, motor, and autonomic neuropathy severity in clinical trials.
Oxaliplatin-Induced Peripheral Neuropathy Mechanisms
Conducted mechanistic studies elucidating the pathophysiology of oxaliplatin-induced acute neuropathy (cold allodynia via Nav channel modulation) and chronic sensory neuropathy, informing rational design of neuroprotective interventions.
Pharmacological Management of Established CIPN
Contributed clinical evidence supporting duloxetine and SNRIs for established paclitaxel- and oxaliplatin-induced peripheral neuropathy, consistent with ASCO guideline moderate-evidence recommendations.
Representative Works 代表性著作
Oxaliplatin-Induced Peripheral Neuropathy: Pathomechanisms and Clinical Management
Nature Reviews Neurology (2019)
Comprehensive mechanistic and clinical review of oxaliplatin neuropathy, covering acute and chronic forms, electrophysiology, biomarkers, and therapeutic options.
Validation of the EORTC QLQ-CIPN20 in Patients Receiving Neurotoxic Chemotherapy
European Journal of Cancer (2015)
Multicenter psychometric validation of the EORTC CIPN-20 patient-reported outcome questionnaire, establishing its reliability and responsiveness across chemotherapy regimens.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-20 | All information from publicly available academic sources
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