Cynthia Wetmore
辛西娅·韦特莫尔
MD, PhD
Section Chief, Pediatric Neuro-Oncology; Professor of Pediatrics儿童神经肿瘤科主任；儿科学教授
👥Biography 个人简介
Cynthia Wetmore is a leading pediatric neuro-oncologist at Children's Hospital Colorado who serves as a principal investigator for multiple Children's Oncology Group ACNS trials, focuses on reducing treatment-related neurotoxicity in pediatric brain tumor survivors, and pioneers molecular approaches to low-grade glioma management.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
COG ACNS Clinical Trials Leadership
Serves as principal investigator on multiple COG ACNS consortium trials including ACNS1422 (BRAF-inhibitor LGG trial) and ACNS1833, advancing evidence-based standard of care.
Pediatric Low-Grade Glioma Management
Led studies establishing BRAF fusion and BRAF V600E mutation testing as standard for pediatric LGG, enabling targeted therapy with MEK/BRAF inhibitors as first-line treatment.
Neurocognitive Late Effects Research
Conducted prospective studies quantifying neurocognitive decline after cranial radiation in pediatric brain tumor patients, informing risk-adapted approaches to minimize long-term sequelae.
Representative Works 代表性著作
BRAF inhibition in pediatric low-grade glioma: ACNS1422 phase II results
Journal of Clinical Oncology (2023)
Phase II results demonstrating superior response rate of dabrafenib/trametinib versus chemotherapy in BRAF V600E-mutant pediatric LGG.
Neurocognitive outcomes in pediatric brain tumor survivors treated with proton versus photon therapy
Neuro-Oncology (2021)
Prospective comparison showing neurocognitive advantages of proton therapy in pediatric brain tumor treatment.
Molecular classification and therapeutic targets in pediatric low-grade glioma
Cancer Research (2019)
Comprehensive genomic characterization of pediatric LGG establishing BRAF, FGFR, and MYB alterations as actionable targets.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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