Cornelia Trimble
科妮莉亚·特林布尔
MD
Professor of Gynecology and Obstetrics, Oncology, and Pathology; Director, Gynecologic Cancer Immunotherapy妇产科学、肿瘤学及病理学教授；妇科肿瘤免疫治疗主任
👥Biography 个人简介
Leading researcher in HPV therapeutic vaccines targeting cervical intraepithelial neoplasia (CIN) to prevent progression to cervical cancer. Directed clinical trials of ADXS11-001 (Lm-LLO-E7) for CIN3. Pioneer in the concept of treating pre-malignant lesions with immunotherapy to intercept cancer.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
HPV Therapeutic Vaccine Trials
Led clinical trials of ADXS11-001 Listeria-based therapeutic vaccine for CIN2/3, demonstrating regression of precancerous lesions and providing proof-of-concept for cancer interception immunotherapy.
Cancer Interception Framework
Advanced the scientific and clinical framework for treating precancerous HPV lesions with immunotherapy, bridging preventive oncology with therapeutic intervention at the pre-malignant stage.
Representative Works 代表性著作
Safety and efficacy of a modified antigen-specific immunotherapy targeting HPV-16 positive CIN 2/3
Science Translational Medicine (2015)
Clinical trial showing regression of CIN2/3 lesions following therapeutic DNA vaccination targeting HPV-16 E6/E7 oncoproteins.
Regression of high-grade cervical intraepithelial neoplasia with GX-188E therapeutic DNA vaccine
The Lancet (2014)
Demonstrated significant CIN3 lesion regression with therapeutic HPV vaccination, validating cancer interception through immunotherapy.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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