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clinical / clinicalprecision oncology biomarkers

Ingrid Winship

英格丽德·温希普

MBBS, MD, FRACP, FRCPA

🏢The University of Melbourne / Royal Melbourne Hospital(墨尔本大学 / 皇家墨尔本医院)🌐Australia

Professor of Adult Clinical Genetics; Head, Genomic Medicine成人临床遗传学教授;基因组医学主任

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Key Papers
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Key Contributions

👥Biography 个人简介

Ingrid Winship, MBBS, MD, FRACP, FRCPA is Professor of Adult Clinical Genetics and Head of Genomic Medicine at the University of Melbourne and Royal Melbourne Hospital. She is a leading international authority on hereditary cancer syndromes, polygenic risk scoring (PRS) for cancer prevention, and the translation of population-level cancer genomics into clinical practice. Winship has been central to the Australian Genomics Health Alliance (AGHA) and has led population-based programs demonstrating the real-world utility of polygenic risk scores for stratifying breast, colorectal, and prostate cancer risk in clinical settings. Her work integrates germline pathogenic variant testing with polygenic risk scoring to create comprehensive cancer risk profiles for prevention counseling, demonstrating that PRS adds meaningful discrimination to monogenic risk models. She has also been a leader in evaluating real-world evidence for biomarker-driven hereditary cancer screening programs, including universal Lynch syndrome testing in colorectal cancer. Winship serves on multiple Australian and international genomic medicine guideline committees and has published over 250 peer-reviewed articles.

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🧪Research Fields 研究领域

Polygenic Risk Scoring for Cancer癌症多基因风险评分
Hereditary Cancer Syndromes遗传性癌症综合征
Genomic Cancer Prevention基因组癌症预防
Real-World Evidence for Biomarker Screening生物标志物筛查真实世界证据
Population Cancer Genomics人群癌症基因组学

🎓Key Contributions 主要贡献

Polygenic Risk Scoring for Breast and Colorectal Cancer Prevention

Led clinical validation studies integrating polygenic risk scores (PRS) with pathogenic BRCA1/2 and MMR gene variants to create composite cancer risk models, demonstrating that PRS significantly refines risk stratification beyond monogenic testing alone and enables more personalized prevention and screening recommendations.

Universal Lynch Syndrome Testing: Real-World Evidence

Directed population-based real-world evidence programs implementing universal mismatch repair IHC and MSI testing in all newly diagnosed colorectal cancers in Australian health systems, establishing clinical effectiveness of universal Lynch syndrome screening and informing national policy recommendations.

Population Genomics for Cancer Risk Stratification

Led the Cancer Genomics Program within Australian Genomics, developing infrastructure and evidence frameworks for population-scale cancer genomic risk stratification, demonstrating the feasibility and clinical utility of integrating germline and polygenic risk data into routine cancer screening programs.

Representative Works 代表性著作

[1]

Polygenic risk scores for the improvement of cancer risk stratification

Nature Reviews Genetics (2022)

Comprehensive review of polygenic risk score development and clinical validation for breast, colorectal, and prostate cancer, evaluating the evidence base for PRS integration into population cancer prevention programs.

[2]

Universal mismatch repair testing of colorectal cancers in an Australian tertiary health service

Journal of Medical Genetics (2020)

Real-world evaluation of universal MMR IHC screening in all newly diagnosed colorectal cancers, demonstrating the diagnostic yield for Lynch syndrome and informing universal testing policy adoption.

🏆Awards & Recognition 奖项与荣誉

🏆Australian Society of Medical Research Distinguished Achievement Award
🏆Human Genetics Society of Australasia Founders Award
🏆Colorectal Cancer Australia Research Excellence Award

📄Data Sources 数据来源

Last updated: 2026-01-15 | All information from publicly available academic sources

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