Bradley J. Monk
布拉德利·蒙克
MD, FACS, FACOG
Chief, Division of Gynecologic Oncology妇科肿瘤学部主任
👥Biography 个人简介
Bradley Monk is one of the most prolific clinical trial investigators in gynecologic oncology, having contributed to pivotal trials across cervical, ovarian, and endometrial cancers. He was principal investigator for GOG 240 establishing bevacizumab as standard therapy in cervical cancer, and led or contributed to the PRIMA trial establishing niraparib maintenance as first-line maintenance after platinum-based therapy in ovarian cancer regardless of BRCA status. Monk has championed the use of VEGF pathway inhibitors and PARP inhibitors in gynecologic cancers and has extensive experience in patient-reported outcomes in clinical trials.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Bevacizumab in Cervical Cancer
Led GOG 240, the pivotal trial demonstrating bevacizumab added to platinum-based doublet chemotherapy significantly improves overall survival in recurrent/metastatic cervical cancer, establishing VEGF inhibition as standard care.
Niraparib All-Comer Maintenance
Led PRIMA trial establishing niraparib maintenance benefit in all platinum-sensitive ovarian cancer patients regardless of BRCA/HRD status, expanding PARP inhibitor use beyond BRCA-mutated populations.
Representative Works 代表性著作
Bevacizumab for the Treatment of Cervical Cancer
New England Journal of Medicine (2014)
GOG 240 establishing bevacizumab in cervical cancer standard care.
Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer
New England Journal of Medicine (2016)
ENGOT-OV16/NOVA trial establishing niraparib in ovarian cancer maintenance.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Carlos H. Barrios
PUCRS (Pontifical Catholic University of Rio Grande do Sul) / Hospital São Lucas, Porto Alegre, Brazil
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