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clinical / clinicalcervical cancer and ovarian cancer trials

Bradley J. Monk

布拉德利·蒙克

MD, FACS, FACOG

🏢HonorHealth Research Institute(荣誉健康研究所)🌐USA

Chief, Division of Gynecologic Oncology妇科肿瘤学部主任

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Bradley Monk is one of the most prolific clinical trial investigators in gynecologic oncology, having contributed to pivotal trials across cervical, ovarian, and endometrial cancers. He was principal investigator for GOG 240 establishing bevacizumab as standard therapy in cervical cancer, and led or contributed to the PRIMA trial establishing niraparib maintenance as first-line maintenance after platinum-based therapy in ovarian cancer regardless of BRCA status. Monk has championed the use of VEGF pathway inhibitors and PARP inhibitors in gynecologic cancers and has extensive experience in patient-reported outcomes in clinical trials.

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🧪Research Fields 研究领域

cervical cancer clinical trials宫颈癌临床试验
ovarian cancer maintenance therapy卵巢癌维持治疗
bevacizumab cervical cancer贝伐珠单抗宫颈癌
PARP inhibitorsPARP抑制剂
niraparib尼拉帕尼

🎓Key Contributions 主要贡献

Bevacizumab in Cervical Cancer

Led GOG 240, the pivotal trial demonstrating bevacizumab added to platinum-based doublet chemotherapy significantly improves overall survival in recurrent/metastatic cervical cancer, establishing VEGF inhibition as standard care.

Niraparib All-Comer Maintenance

Led PRIMA trial establishing niraparib maintenance benefit in all platinum-sensitive ovarian cancer patients regardless of BRCA/HRD status, expanding PARP inhibitor use beyond BRCA-mutated populations.

Representative Works 代表性著作

[1]

Bevacizumab for the Treatment of Cervical Cancer

New England Journal of Medicine (2014)

GOG 240 establishing bevacizumab in cervical cancer standard care.

[2]

Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer

New England Journal of Medicine (2016)

ENGOT-OV16/NOVA trial establishing niraparib in ovarian cancer maintenance.

🏆Awards & Recognition 奖项与荣誉

🏆SGO Distinguished Service Award
🏆GOG Investigator of the Year Award

📄Data Sources 数据来源

Last updated: 2026-01-15 | All information from publicly available academic sources

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