Bernard Escudier
贝纳尔·埃斯屈迪耶
MD
Senior Consultant, Department of Medical Oncology肿瘤内科高级顾问
👥Biography 个人简介
Bernard Escudier, MD is a Senior Consultant in the Department of Medical Oncology at Institut Gustave Roussy, France's leading cancer center. He is widely regarded as one of the founding fathers of modern targeted therapy for renal cell carcinoma, having led pivotal trials that established sorafenib and everolimus as RCC standards of care. His RECORD-1 trial defined the post-sunitinib treatment landscape for over a decade.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Sorafenib Development in RCC
Co-led the pivotal phase III TARGET trial demonstrating PFS benefit for sorafenib versus placebo in cytokine-refractory advanced RCC, leading to the first FDA-approved targeted agent for kidney cancer and inaugurating the VEGFR inhibitor era.
RECORD-1: Everolimus After VEGFR Inhibitor Failure
Led RECORD-1, the phase III trial establishing everolimus as the standard second-line therapy after sunitinib or sorafenib failure in advanced RCC, defining sequential targeted therapy as a viable strategy in kidney cancer.
ESMO RCC Clinical Practice Guidelines
Served as lead author on multiple editions of the European Society for Medical Oncology (ESMO) clinical practice guidelines for renal cell carcinoma, shaping evidence-based treatment standards across Europe and internationally.
Representative Works 代表性著作
Sorafenib in Advanced Clear-Cell Renal-Cell Carcinoma
New England Journal of Medicine (2007)
TARGET trial demonstrating PFS benefit for sorafenib in cytokine-refractory advanced clear-cell RCC, establishing the first VEGFR inhibitor as a standard of care for kidney cancer.
Everolimus for Advanced Renal-Cell Carcinoma
The Lancet (2008)
RECORD-1 phase III trial showing PFS benefit for everolimus after VEGFR TKI failure, establishing mTOR inhibition as a second-line standard and defining sequential therapy in advanced RCC.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Toni K. Choueiri
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Sumanta Pal
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