Bas P.L. Wijnhoven
巴斯·韦恩霍芬
MD, PhD
Professor of Surgery; Head, Upper GI and Esophageal Surgery; CROSS Trial Investigator外科学教授;上消化道与食管外科主任;CROSS试验研究者
👥Biography 个人简介
Bas P.L. Wijnhoven, MD, PhD is Professor of Surgery and Head of Upper GI and Esophageal Surgery at Erasmus MC University Medical Center Rotterdam. He is a leading esophageal surgeon and clinical trialist in the Netherlands and Europe, and a principal investigator in several landmark trials that have shaped modern esophageal cancer management—most notably the CROSS trial series and the ROBOT randomized controlled trial comparing robot-assisted minimally invasive esophagectomy to open esophagectomy. As a surgical leader at Erasmus MC, Wijnhoven has worked alongside van Lanschot in the CROSS and SANO trial programs and has been central to establishing Rotterdam as a globally recognized center for esophageal cancer excellence. He led the ROBOT trial (van der Sluis et al., NEJM 2023), the definitive phase III randomized trial showing that robot-assisted minimally invasive esophagectomy (RAMIE) reduced postoperative complications—particularly pulmonary complications—compared to open transthoracic esophagectomy, while demonstrating equivalent oncological outcomes and superior functional recovery, paving the way for robot-assisted approaches as a new standard for surgical esophagectomy. Wijnhoven has also contributed extensively to quality-of-life research after esophagectomy, CROSS long-term outcome analyses, and the SANO active surveillance trial program. His broader research interests include enhanced recovery, complications management, and surgical outcomes registries. He is a highly regarded surgical educator, and his technical contributions to minimally invasive and robot-assisted esophagectomy have been widely disseminated through surgical workshops and peer-reviewed publications.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
ROBOT Trial — Robot-Assisted Versus Open Transthoracic Esophagectomy
Led the ROBOT phase III randomized trial demonstrating that robot-assisted minimally invasive esophagectomy (RAMIE) significantly reduced postoperative complications (59% vs. 80%) and improved postoperative quality of life compared to open esophagectomy, while maintaining equivalent oncological outcomes, establishing RAMIE as a preferred surgical approach.
CROSS Trial — Surgical Outcomes and Long-Term Survival Analyses
Contributed surgical leadership to the CROSS phase III trial and subsequent long-term analyses demonstrating durable survival benefit with neoadjuvant chemoradiotherapy (carboplatin/paclitaxel + RT) followed by surgery versus surgery alone in resectable esophageal cancer.
SANO Trial — Active Surveillance After Complete Response to Chemoradiotherapy
Participated in the SANO randomized phase II–III trial evaluating organ-preserving active surveillance as an alternative to immediate esophagectomy in patients with clinical complete response to neoadjuvant chemoradiotherapy, supporting the safety of a watch-and-wait approach.
Quality of Life and Functional Recovery After Esophagectomy
Led systematic quality-of-life assessments in the ROBOT and CROSS trial cohorts, demonstrating superior physical functioning, reduced pain, and improved dysphagia scores with minimally invasive and robot-assisted approaches, contributing to patient-centered surgical decision-making.
Representative Works 代表性著作
Robot-assisted minimally invasive thoracolaparoscopic esophagectomy versus open transthoracic esophagectomy for resectable esophageal cancer (ROBOT): a randomised controlled trial
New England Journal of Medicine (2023)
Landmark ROBOT trial demonstrating that RAMIE significantly reduced postoperative complications and improved early quality of life compared to open esophagectomy with equivalent 3-year oncological outcomes, supporting RAMIE as a new surgical standard.
Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial
The Lancet Oncology (2015)
Long-term CROSS data demonstrating sustained survival benefit of neoadjuvant chemoradiotherapy; the standard-setting trial co-authored by the Erasmus MC group.
Organ-sparing surgery after neoadjuvant chemoradiotherapy in patients with locally advanced oesophageal cancer (SANO): results of a randomised phase II–III trial
The Lancet Oncology (2023)
SANO trial demonstrating non-inferior overall survival with active surveillance (watch-and-wait) versus standard surgery after clinical complete response to neoadjuvant chemoradiotherapy in esophageal cancer.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Hope S. Rugo
University of California, San Francisco (UCSF)
Maryam B. Lustberg
Yale School of Medicine / Yale Cancer Center
Sara M. Tolaney
Dana-Farber Cancer Institute / Harvard Medical School
Carlos H. Barrios
PUCRS (Pontifical Catholic University of Rio Grande do Sul) / Hospital São Lucas, Porto Alegre, Brazil
关注 巴斯·韦恩霍芬 的研究动态
Follow Bas P.L. Wijnhoven's research updates
留下邮箱,当我们发布与 Bas P.L. Wijnhoven(Erasmus MC University Medical Center Rotterdam)相关的新研究或访谈时,我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment