Anne Lynn S. Chang
安妮·林·张
MD
Associate Professor of Dermatology; Director, High Risk Skin Cancer Clinic皮肤科副教授；高风险皮肤癌诊所主任
👥Biography 个人简介
Anne Lynn Chang is a dermatologic oncologist and Associate Professor at Stanford University with specialized expertise in advanced basal cell carcinoma. She was among the first investigators to study vismodegib and sonidegib in clinical trials, contributing to their regulatory approvals. Her laboratory and clinical work spans Hedgehog pathway biology in skin carcinogenesis, drug resistance mechanisms to smoothened inhibitors, and the emerging role of cemiplimab for BCC patients progressing on Hedgehog-targeted therapy.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Hedgehog Inhibitor Clinical Development
Participated in early phase trials of vismodegib and sonidegib at Stanford, helping establish efficacy and safety data that supported FDA approvals for locally advanced and metastatic basal cell carcinoma.
Drug Resistance in Advanced BCC
Characterized mechanisms of acquired resistance to smoothened inhibitors including SMO mutations and alternative Hedgehog pathway activation, informing strategies for sequential and combination therapies.
Representative Works 代表性著作
Cemiplimab in locally advanced basal cell carcinoma after hedgehog inhibitor therapy: an open-label, multi-centre, single-arm, phase 2 trial
The Lancet Oncology (2021)
Pivotal trial demonstrating cemiplimab activity in advanced BCC patients who progressed on or were intolerant to Hedgehog pathway inhibitors, leading to FDA approval.
Resistance to vismodegib in advanced basal cell carcinoma: mechanisms and clinical implications
JAMA Dermatology (2022)
Comprehensive analysis of smoothened mutations and bypass pathway activation underlying clinical resistance to vismodegib in advanced BCC.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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Carlos H. Barrios
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