Andreas Mildner
安德烈亚斯·米尔德纳
PhD
Senior Scientist, Department of Immunology and Regenerative Biology免疫学与再生生物学系高级科学家
👥Biography 个人简介
Andreas Mildner at the Weizmann Institute is an expert in myeloid cell ontogeny and tumor-associated macrophage biology. His single-cell and fate-mapping studies have defined the origin, heterogeneity, and functional states of TAMs and monocyte subsets in tumors, providing a cellular atlas that informs therapeutic reprogramming of the myeloid compartment.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Monocyte Subset Diversity and Tumor Infiltration
Characterized Ly6C-high and Ly6C-low monocyte subsets and their differential recruitment and differentiation into TAMs within tumors, defining how systemic monocyte heterogeneity shapes local myeloid composition and immunosuppression.
Fate-Mapping of Tumor-Associated Macrophages
Used genetic fate-mapping and parabiosis to show that TAM populations arise from both embryonic precursors and monocyte recruitment in a tumor-type and stage-dependent manner, explaining why TAM composition varies across cancer types.
Single-Cell Transcriptomic Atlas of Myeloid Cells in Tumors
Contributed to single-cell RNA-seq atlases resolving the full spectrum of myeloid states within human and mouse tumors, identifying immunosuppressive TAM subsets and candidate surface markers for targeted depletion.
Representative Works 代表性著作
Mononuclear phagocyte heterogeneity in the nervous system: danger signal-driven activation of resident microglia vs. recruitment of CCR2+ monocytes
Glia (2011)
Defined the differential contributions of resident microglia and recruited monocytes in CNS pathology, establishing key concepts in tissue macrophage heterogeneity with direct implications for brain tumor immunity.
Tumor-associated macrophages: from mechanisms to therapy
Immunity (2014)
Comprehensive mechanistic review covering TAM origin, polarization, tumor-promoting functions, and therapeutic strategies to target or reprogram immunosuppressive macrophages.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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