Ana Oaknin
安娜·奥克宁
MD, PhD
Head, Gynaecological Tumours Group妇科肿瘤组组长
👥Biography 个人简介
Ana Oaknin is a gynecologic oncologist at VHIO who has led pivotal trials bringing immunotherapy to cervical and endometrial cancer. She was a key investigator in the KEYNOTE-826 trial establishing pembrolizumab plus chemotherapy as standard first-line therapy for persistent, recurrent, or metastatic cervical cancer, and contributed to GARNET establishing dostarlimab in endometrial cancer. Oaknin has driven understanding of molecular subtypes in gynecologic cancers, particularly the prognostic and therapeutic implications of POLE mutations, MSI-H status, and p53 alterations in endometrial cancer.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Immunotherapy in Cervical Cancer
Contributed to KEYNOTE-826 establishing pembrolizumab combined with chemotherapy as standard first-line therapy for recurrent/metastatic cervical cancer, transforming outcomes in this high-mortality disease.
Molecular Subtyping of Endometrial Cancer
Advanced clinical application of TCGA-based molecular classification of endometrial cancer, demonstrating that POLE, MSI-H, and TP53 subtypes require distinct therapeutic approaches and have markedly different prognoses.
Representative Works 代表性著作
Pembrolizumab with or without Chemotherapy versus Chemotherapy for Advanced Cervical Cancer
New England Journal of Medicine (2021)
KEYNOTE-826 trial establishing pembrolizumab in cervical cancer.
Dostarlimab for Endometrial Cancer with Mismatch-Repair Deficiency
New England Journal of Medicine (2021)
GARNET trial establishing dostarlimab in dMMR endometrial cancer.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Hope S. Rugo
University of California, San Francisco (UCSF)
Maryam B. Lustberg
Yale School of Medicine / Yale Cancer Center
Sara M. Tolaney
Dana-Farber Cancer Institute / Harvard Medical School
Carlos H. Barrios
PUCRS (Pontifical Catholic University of Rio Grande do Sul) / Hospital São Lucas, Porto Alegre, Brazil
关注 安娜·奥克宁 的研究动态
Follow Ana Oaknin's research updates
留下邮箱，当我们发布与 Ana Oaknin（Vall d'Hebron Institute of Oncology (VHIO)）相关的新研究或访谈时，我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment