Adil Daud
阿迪尔·达乌德
MD
Clinical Professor of Medicine; Director, Melanoma Clinical Research医学临床教授；黑色素瘤临床研究主任
👥Biography 个人简介
Dr. Daud leads melanoma clinical research at UCSF and is a pioneer in exploring CDK4/6 inhibition combined with BRAF-targeted therapy in melanoma. His work on ribociclib plus targeted agents and the immunological consequences of cell-cycle checkpoint inhibition has opened a new combinatorial frontier in BRAF-mutant melanoma.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
CDK4/6 Inhibition in Melanoma (Ribociclib Combinations)
Pioneered clinical trials combining ribociclib with BRAF/MEK inhibitors in BRAF-mutant melanoma, demonstrating that CDK4/6 blockade enhances immune infiltration and overcomes adaptive targeted-therapy resistance.
Tumor Microenvironment Modulation
Led translational studies showing that PD-1 blockade response correlates with pre-treatment T-cell infiltration patterns and that TME remodeling can be exploited by combinatorial IO and targeted strategies in melanoma.
Representative Works 代表性著作
Antitumor activity of pembrolizumab in biomarker-unselected patients with recurrent and/or metastatic head and neck squamous cell carcinoma and correlation of response with PD-L1 and p16 status
Journal of Clinical Oncology (2016)
Contributed to correlative biomarker work informing IO response prediction across tumor types including melanoma.
CDK4/6 inhibition with ribociclib combined with targeted therapy in BRAF-mutant melanoma: phase Ib/II results
Cancer Discovery (2023)
First clinical evidence that ribociclib plus BRAF/MEK inhibitors delays resistance and remodels the immune microenvironment in metastatic BRAF V600–mutant melanoma.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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University Hospital Essen (Universitätsklinikum Essen)
Suzanne George
Dana-Farber Cancer Institute / Harvard Medical School
Marcia S. Brose
Sidney Kimmel Cancer Center, Thomas Jefferson University
Lori J. Wirth
Massachusetts General Hospital, Harvard Medical School
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留下邮箱，当我们发布与 Adil Daud（University of California San Francisco (UCSF) Helen Diller Family Comprehensive Cancer Center）相关的新研究或访谈时，我们会通知你。
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