Yibin Kang
康毅滨
PhD
Warner-Lambert/Parke-Davis Professor of Molecular Biology华纳-兰伯特/帕克-戴维斯分子生物学讲席教授
👥Biography 个人简介
Yibin Kang is a leading authority on cancer metastasis at Princeton University. His laboratory has made seminal contributions to understanding bone and lung metastasis in breast cancer, identifying key molecular drivers including the VCAM-1/Ezrin axis and osteolytic metastasis regulators. His work bridges cancer cell biology with clinical translational applications.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Bone Metastasis Mechanisms
Identified gene signatures and molecular pathways—including Jagged1-Notch and IL-11 signaling—that enable breast cancer cells to colonize and destroy bone tissue.
Lung Metastasis Biology
Discovered VCAM-1 and macrophage-mediated survival mechanisms that allow metastatic cells to survive and proliferate in the lung microenvironment.
Metastatic Dormancy and Reactivation
Investigated signals from the bone marrow niche that maintain disseminated tumor cell dormancy and trigger reactivation, illuminating late-recurrence biology.
Representative Works 代表性著作
A multigenic program mediating breast cancer metastasis to bone
Cancer Cell (2003)
Defined a gene expression program governing breast cancer osteolytic bone metastasis, establishing a paradigm for organ-specific colonization studies.
VCAM-1 mediates lung-specific metastasis by recruiting osteoclast precursors
Cancer Cell (2011)
Revealed VCAM-1 on cancer cells recruits pro-metastatic macrophages in the lung to promote outgrowth of metastatic colonies.
Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug induction in breast cancers
Nature Cell Biology (2011)
Established Jagged1-Notch as a key axis driving EMT and bone metastasis in breast cancer.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Lewis Cantley
Weill Cornell Medicine
Craig Thompson
Memorial Sloan Kettering Cancer Center
Matthew Vander Heiden
Massachusetts Institute of Technology
Navdeep Chandel
Northwestern University Feinberg School of Medicine
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