Victor E. Velculescu

Victor Velculescu is a Professor of Oncology at Johns Hopkins University School of Medicine and co-director of the Cancer Biology program. He is one of the founding pioneers of liquid biopsy and circulating tumor DNA (ctDNA) technology for cancer early detection and monitoring. Velculescu's laboratory co-developed SAGE (Serial Analysis of Gene Expression) and was one of the first to detect ctDNA in blood plasma of cancer patients. He co-founded Personal Genome Diagnostics (PGDx), which commercialized ctDNA-based cancer genotyping tests used clinically worldwide. His landmark studies demonstrated that ctDNA can detect early-stage cancers across multiple types from a single blood draw, and that ctDNA mutation profiles accurately reflect tumor genomic heterogeneity. His work underpins the multi-cancer early detection (MCED) blood test concept.

Victor Velculescu 是约翰·霍普金斯大学医学院肿瘤学教授，也是癌症生物学项目的联合主任。他是液体活检和循环肿瘤DNA（ctDNA）技术用于癌症早期检测和监测的奠基性先驱之一。 Velculescu的实验室共同开发了SAGE（基因表达的序列分析），并率先在癌症患者血浆中检测到ctDNA。他共同创立了Personal Genome Diagnostics（PGDx），商业化了全球临床使用的基于ctDNA的癌症基因型检测。