Ulrich Keilholz
乌尔里希·凯尔霍尔茨
MD
Director of the Comprehensive Cancer Center Charité (CCCC)夏里特综合癌症中心主任
👥Biography 个人简介
Professor Ulrich Keilholz directs the Charité Comprehensive Cancer Center in Berlin and is a leading European expert in melanoma and head and neck cancers. He has made major contributions to immunotherapy, T-cell therapy for melanoma, and cetuximab combinations in head and neck squamous cell carcinoma.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Melanoma Immunotherapy
Conducted landmark early trials of interleukin-based immunotherapy and later checkpoint inhibitors in melanoma, helping define predictive markers and combination approaches for durable response.
Head and Neck Squamous Cell Carcinoma
Contributed to EXTREME and TPEx trial data supporting platinum-cetuximab regimens, and led translational work on HPV status and immune contexture in HNSCC prognosis.
Cancer Center Leadership
Built the CCCC into a nationally designated comprehensive cancer center integrating tumor boards, precision diagnostics, and early-phase trials, serving as a model for German oncology.
Representative Works 代表性著作
Ipilimumab in advanced melanoma: long-term survival analysis
Journal of Clinical Oncology (2014)
Pooled analysis confirming durable long-term survival plateau with ipilimumab, establishing the curative potential of CTLA-4 blockade in advanced melanoma.
Dacarbazine versus dacarbazine plus interferon in advanced melanoma
Journal of Clinical Oncology (2002)
Established evidence base for systemic therapy in pre-immunotherapy era melanoma, providing benchmark survival data referenced in subsequent immunotherapy trials.
Cetuximab plus platinum-based chemotherapy in recurrent or metastatic head and neck cancer
Annals of Oncology (2010)
Contributed translational analyses supporting cetuximab combination utility in HNSCC, informing EXTREME regimen adoption as standard first-line treatment.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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