research / researchCancer RNA Biology

Ting Wang

王汀

PhD

🏢Washington University in St. Louis(圣路易斯华盛顿大学)🌐USA

Professor of Genetics; Director, Institute for Informatics, Data Science and Biostatistics遗传学教授；信息学、数据科学与生物统计学研究所所长

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Key Papers

Awards

Key Contributions

👥Biography 个人简介

Leader in transposable element (TE) biology and their role in generating non-coding RNAs and regulatory elements in cancer. Pioneer in cancer epigenomics showing how TE-derived sequences reshape the cancer transcriptome and immunogenicity.

🧪Research Fields 研究领域

Transposable Elements and RNA转座子与RNA

Cancer Epigenomics癌症表观基因组学

Endogenous Retroviruses内源性逆转录病毒

Non-Coding RNA Regulation非编码RNA调控

Comparative Epigenomics比较表观基因组学

🎓Key Contributions 主要贡献

Transposable Elements in Cancer RNA

Demonstrated that transposable elements are derepressed in cancer to produce novel non-coding RNAs and act as enhancers that rewire cancer transcriptional programs.

Endogenous Retrovirus Cancer Immunotherapy

Showed that endogenous retroviral elements activated in cancer produce immunogenic dsRNA that can be harnessed to enhance cancer immunotherapy responses.

Representative Works 代表性著作

[1]

Transposable elements rewire the transcriptomic regulatory landscape in human colorectal cancer

Nature Communications (2019)

Systematic analysis showing TEs create thousands of novel cancer-specific regulatory elements and non-coding RNAs.

[2]

Endogenous retroviral insertions can generate heritable enhancers and silencers in human populations

eLife (2016)

Demonstrated ERV-derived regulatory sequences reshape the human transcriptome including in cancer.

[3]

Harnessing endogenous retroviruses to improve cancer immunotherapy

Science Immunology (2021)

Strategy to activate TE-derived immunogenic RNA to improve anti-tumor immune responses.

🏆Awards & Recognition 奖项与荣誉

🏆NIH Director's New Innovator Award

🏆Mallinckrodt Foundation Award

🏆ENCODE Consortium Principal Investigator

📄Data Sources 数据来源

Institution

Last updated: 2026-01-15 | All information from publicly available academic sources

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