Tanios Bekaii-Saab
塔尼奥斯·贝凯-萨阿布
MD, FACP
Vice Chair, Division of Hematology/Oncology; Professor of Medicine血液/肿瘤科副主任；医学教授
👥Biography 个人简介
Dr. Tanios Bekaii-Saab is a prolific GI oncologist at Mayo Clinic Arizona with deep expertise in BRAF-mutated colorectal cancer, hepatobiliary malignancies, and novel drug development. He has led over 100 clinical trials and contributed pivotal data establishing targeted therapy standards in GI oncology.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
BRAF V600E-Targeted Therapy in Colorectal Cancer
Led BEACON CRC trial demonstrating encorafenib plus cetuximab improved OS in BRAF V600E-mutated metastatic colorectal cancer, establishing a new standard of care.
Biliary Tract Cancer Drug Development
Contributed to trials of FGFR inhibitors and IDH1 inhibitors in cholangiocarcinoma, advancing molecularly guided therapy in biliary tract cancers.
Representative Works 代表性著作
Encorafenib, binimetinib, and cetuximab in BRAF V600E-mutated colorectal cancer (BEACON CRC)
New England Journal of Medicine (2019)
Definitive trial showing superior OS with BRAF/MEK/EGFR triple blockade vs standard therapy in BRAF V600E CRC; led to FDA approval.
Regorafenib dose-optimisation in patients with refractory metastatic colorectal cancer (ReDOS)
Lancet Oncology (2019)
Showed that dose-escalation strategy with regorafenib improved tolerability and clinical outcomes compared to standard dosing in refractory CRC.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Johanna Bendell
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