Suzanne Lentzsch
苏珊娜·伦茨施
MD, PhD
Director, Multiple Myeloma Program & Professor of Medicine多发性骨髓瘤项目主任暨医学教授
👥Biography 个人简介
Suzanne Lentzsch leads the Columbia University myeloma program and is an internationally recognized expert in plasma cell biology and BCL-2 inhibition in myeloma. She defined the t(11;14) translocation as a predictive biomarker for venetoclax sensitivity, transforming precision therapy in myeloma.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Venetoclax in t(11;14) Myeloma
Led pivotal translational and clinical studies demonstrating that BCL-2 overexpression driven by t(11;14) translocation sensitizes myeloma cells to venetoclax, enabling precision selection of patients for BCL-2 inhibitor therapy.
Plasma Cell Biology and Myeloma Pathogenesis
Investigated molecular mechanisms governing plasma cell differentiation and survival in the bone marrow microenvironment, identifying novel therapeutic vulnerabilities in myeloma and Waldenström macroglobulinemia.
Novel Combinations with Venetoclax
Designed and led clinical trials examining venetoclax combinations with daratumumab and bortezomib in t(11;14) myeloma, establishing response rates and safety profiles informing current trial design.
Representative Works 代表性著作
Venetoclax Monotherapy in Relapsed/Refractory t(11;14) Multiple Myeloma
Journal of Clinical Oncology (2021)
Phase II study demonstrating high response rates with venetoclax monotherapy in t(11;14) myeloma, establishing proof of concept for BCL-2 inhibition.
BCL-2 Dependence and Venetoclax Sensitivity in Multiple Myeloma
Blood (2018)
Mechanistic study identifying t(11;14) translocation and BCL-2 high/BCL-XL low expression as predictors of venetoclax sensitivity.
Venetoclax, Daratumumab, and Dexamethasone in t(11;14) Myeloma
Blood Cancer Journal (2023)
Phase I/II trial of triple combination showing deep responses and manageable safety in relapsed t(11;14) myeloma.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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留下邮箱，当我们发布与 Suzanne Lentzsch（Columbia University Irving Medical Center）相关的新研究或访谈时，我们会通知你。
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