Sangeeta N. Bhatia
桑吉塔·巴蒂亚
MD, PhD
John J. and Dorothy Wilson Professor, IMES & EECS; Howard Hughes Medical Institute Investigator威尔逊讲席教授，IMES与EECS；霍华德·休斯医学研究所研究员
👥Biography 个人简介
Pioneer in liver-targeted nanomedicine, microfluidic liver organoids, and nanosensor-based cancer diagnostics. Developed protease-activated nanosensors for early cancer detection via urine. HHMI Investigator and MacArthur Fellow combining tissue engineering with targeted nanoparticle drug delivery.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Protease-Activated Urine Nanosensors for Cancer Detection
Engineered nanoparticles that sense tumor-associated proteases in vivo and shed reporter peptides detectable in urine, enabling non-invasive early cancer detection in mouse models.
Liver-Targeted siRNA Nanoparticles
Developed LNP and polymer nanoparticle systems for hepatocyte-selective siRNA delivery, enabling targeted gene silencing in liver cancer and metabolic disease models.
Representative Works 代表性著作
Noninvasive Detection of Cancer using Activity-Based Nanosensors
Nature Biotechnology (2012)
Demonstrated protease-activated nanosensors enabling colorectal cancer detection via urine biomarkers in mouse models.
Microfluidic Recapitulation of Liver Zonation
PNAS (2016)
Developed microscale liver organoids that model hepatic drug metabolism, enabling nanomedicine testing platforms.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Faisal Mahmood
Brigham and Women's Hospital; Harvard Medical School
Kun-Hsing Yu
Harvard Medical School; Brigham and Women's Hospital
Ziad Obermeyer
University of California, Berkeley; UC San Francisco
Andrew H. Beck
PathAI; Harvard Medical School (formerly)
关注 桑吉塔·巴蒂亚 的研究动态
Follow Sangeeta N. Bhatia's research updates
留下邮箱，当我们发布与 Sangeeta N. Bhatia（Massachusetts Institute of Technology）相关的新研究或访谈时，我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment