Robert A. Weinberg
罗伯特·温伯格
PhD
Member, Whitehead Institute; Daniel K. Ludwig Professor for Cancer Research, MIT怀特黑德研究所成员；麻省理工学院丹尼尔·K·路德维希癌症研究教授
👥Biography 个人简介
Robert Weinberg is among the most influential cancer biologists in history. He co-discovered the first human oncogene (RAS) and the first tumor suppressor gene (RB), co-authored the landmark 'Hallmarks of Cancer' framework, and pioneered the study of EMT and cancer stem cells. His work at MIT and the Whitehead Institute has shaped modern oncology.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Discovery of RAS Oncogene
Co-discovered the first human oncogene (H-RAS) from a human bladder carcinoma, establishing the oncogene paradigm and opening a new era of molecular cancer research.
Hallmarks of Cancer Framework
Co-authored the 'Hallmarks of Cancer' review with Douglas Hanahan, providing a unifying conceptual framework for the biological capabilities acquired during tumor development.
EMT and Cancer Stem Cells
Demonstrated that EMT generates cancer stem cell properties, linking developmental plasticity to tumor-initiating capacity, chemoresistance, and metastatic potential.
Representative Works 代表性著作
The Hallmarks of Cancer
Cell (2000)
Defined six essential biological capabilities enabling cancer development; one of the most cited papers in biomedical research history.
Hallmarks of Cancer: The Next Generation
Cell (2011)
Expanded the original framework to include tumor-promoting inflammation, metabolic reprogramming, immune evasion, and genome instability.
Epithelial-mesenchymal transition and cancer stem cells
Cell (2008)
Demonstrated that EMT induction generates CD44hi/CD24lo cancer stem cell phenotype in human mammary epithelial cells.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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